Microarray detection of Y chromosome deletions associated with male infertility.

Microarray detection of Y chromosome deletions associated with male infertility. Research Abstract Details 

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Microarray detection of Y chromosome deletions associated with male infertility. Abstract Text:

E C Osborne,M Lynch,R McLachlan,A O Trounson,D S Cram,E C Osborne,M Lynch,R McLachlan,A O Trounson,D S Cram,E C Osborne,M Lynch,R McLachlan,A O Trounson,D S Cram,

Array-comparative genomic hybridization (CGH) has emerged as a powerful new molecular tool for the high-resolution analysis of copy-number variation and breakpoint analysis. In this study, array-CGH was used to analyse known Yq deletions associated with male infertility. A microarray platform encompassing probes for chromosomes 13, 14, 21, X and Y was developed in-house and was used to detect different Yq deletion types. The successful application of this array for the detection of Yq deletions involving either the AZFb or AZFc region was demonstrated. Partial and complete AZF deletions were correctly detected in 13 patients with Yq deletions previously identified by multiplex polymerase chain reaction (PCR). This study demonstrates that array-CGH may be an alternative approach to multiplex PCR for the diagnosis of known Yq deletions and potentially a.

Microarray detection of Y chromosome deletions associated with male infertility. Publishing Authors By Initials

EC Osborne,M Lynch,R McLachlan,AO Trounson,DS Cram,EC Osborne,M Lynch,R McLachlan,AO Trounson,DS Cram,EC Osborne,M Lynch,R McLachlan,AO Trounson,DS Cram,

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Microarray detection of Y chromosome deletions associated with male infertility. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Reproductive biomedicine online

VOLUME: 15

Page Numbers: 673-80

Journal Abbreviation: Reprod. Biomed. Online

ISSN: 1472-6483

DAY: 7

MONTH: Dec

YEAR: 2007

Microarray detection of Y chromosome deletions associated with male infertility. Information

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LANGUAGE: eng

NlmUniqueID: 101122473

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Grant and Affiliation Information for Microarray detection of Y chromosome deletions associated with male infertility.

AFFILIATION: Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia; Monash IVF, Clayton, Victoria, Australia.

Country: England

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MEDLINETA: Reprod Biomed Online

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