Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression.

Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression. Research Abstract Details 

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Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression. Abstract Text:

Kate Manley,Gretchen V Gee,Carl P Simkevich,John M Sedivy,Walter J Atwood,

The human polyomavirus, JCV, has a highly restricted tropism and primarily infects glial cells. The mechanisms restricting infection of cells by JCV are poorly understood. Previously we developed and described a glial cell line that was resistant to JCV infection with the aim of using these cells to identify factors that determine JCV tropism. Gene expression profiling of susceptible and resistant glial cells revealed a direct correlation between the expression of inflammatory cytokines and susceptibility to JCV infection. This correlation manifested at the level of viral gene transcription. Previous studies have suggested a link between an increase in cytokine gene expression in HIV patients and the development of PML and these data supports this hypothesis.

Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression. Publishing Authors By Initials

K Manley,GV Gee,CP Simkevich,JM Sedivy,WJ Atwood,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Virology

VOLUME: 366

Page Numbers: 394-404

Journal Abbreviation: Virology

ISSN: 0042-6822

DAY: 6

MONTH: 06

YEAR: 2007

Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression. Information

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LANGUAGE: eng

NlmUniqueID: 110674

Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression. Information

Substance Name: Luciferases

Registry Number: EC 1.13.12.-

Grant and Affiliation Information for Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression.

AFFILIATION: Graduate Program in Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS43097

ACRONYM: NS

MEDLINETA: Virology

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