Micro pumping with cardiomyocyte-polymer hybrid.

Micro pumping with cardiomyocyte-polymer hybrid. Research Abstract Details 

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Micro pumping with cardiomyocyte-polymer hybrid. Abstract Text:

Jungyul Park,Il Chaek Kim,Jeongeun Baek,Misun Cha,Jinseok Kim,Sukho Park,Junghoon Lee,Byungkyu Kim,Jungyul Park,Il Chaek Kim,Jeongeun Baek,Misun Cha,Jinseok Kim,Sukho Park,Junghoon Lee,Byungkyu Kim,

This paper presents a hybrid micropump actuated by the up-down motion of a dome shaped cell-polymer membrane composite. The contractile force induced from self-beating cardiomyocytes cultured on the membrane causes shrinkage and relaxation of a microchamber, leading to a flow in a microchannel. Flow direction is controlled by the geometry of diffuser/nozzle in the microchannel. The fabrication process is noninvasive to cells, thus, cardiomyocytes can robustly maintain their activity for a long time. The fluid motion in the microchannel was monitored by tracking 2 microm polystyrene beads. A net flow rate of 0.226 nl min(-1) was obtained in our microscale device. Our device demonstrates a unique performance of a cell-microdevice hybrid lab-on-a-chip that does not require any external power source, preventing electrical or heat shock to analytes.

Micro pumping with cardiomyocyte-polymer hybrid. Publishing Authors By Initials

J Park,IC Kim,J Baek,M Cha,J Kim,S Park,J Lee,B Kim,J Park,IC Kim,J Baek,M Cha,J Kim,S Park,J Lee,B Kim,

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Micro pumping with cardiomyocyte-polymer hybrid. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Lab on a chip

VOLUME: 7

Page Numbers: 1367-70

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ISSN: 1473-0197

DAY: 20

MONTH: 07

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Micro pumping with cardiomyocyte-polymer hybrid.

AFFILIATION: Biomedical Engineering, Johns Hopkins University, 207 Clark Hall, 3400 N. Charles St., Baltimore, MD 21218, USA. sortpark@gmail.com

Country: England

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MEDLINETA: Lab Chip

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