Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability.

Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Research Abstract Details 

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Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Abstract Text:

Stefan Jacobs,Eva Ruusuvuori,Sampsa T ,Aleksi Haapanen,Helle H Damkier,Ingo Kurth,Moritz Hentschke,Michaela Schweizer,York Rudhard,Linda M Laatikainen,Jaana ,Jeppe Praetorius,Juha Voipio,Christian A ,Stefan Jacobs,Eva Ruusuvuori,Sampsa T Sipilä,Aleksi Haapanen,Helle H Damkier,Ingo Kurth,Moritz Hentschke,Michaela Schweizer,York Rudhard,Linda M Laatikainen,Jaana Tyynelä,Jeppe Praetorius,Juha Voipio,Christian A Hübner,

Members of the SLC4 bicarbonate transporter family are involved in solute transport and pH homeostasis. Here we report that disrupting the Slc4a10 gene, which encodes the Na(+)-coupled Cl(-)-HCO(3)(-) exchanger Slc4a10 (NCBE), drastically reduces brain ventricle volume and protects against fatal epileptic seizures in mice. In choroid plexus epithelial cells, Slc4a10 localizes to the basolateral membrane. These cells displayed a diminished recovery from an acid load in KO mice. Slc4a10 also was expressed in neurons. Within the hippocampus, the Slc4a10 protein was abundant in CA3 pyramidal cells. In the CA3 area, propionate-induced intracellular acidification and attenuation of 4-aminopyridine-induced network activity were prolonged in KO mice. Our data indicate that Slc4a10 is involved in the control of neuronal pH and excitability and may contribute to the secretion of cerebrospinal fluid. Hence, Slc4a10 is a promising pharmacological target for the therapy of epilepsy or elevated intracranial pressure.

Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Publishing Authors By Initials

S Jacobs,E Ruusuvuori,ST ,A Haapanen,HH Damkier,I Kurth,M Hentschke,M Schweizer,Y Rudhard,LM Laatikainen,J ,J Praetorius,J Voipio,CA ,S Jacobs,E Ruusuvuori,ST Sipilä,A Haapanen,HH Damkier,I Kurth,M Hentschke,M Schweizer,Y Rudhard,LM Laatikainen,J Tyynelä,J Praetorius,J Voipio,CA Hübner,

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Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 105

Page Numbers: 311-6

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 1091-6490

DAY: 28

MONTH: 12

YEAR: 2007

Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability.

AFFILIATION: Department of Human Genetics and Zentrum für Molekulare Neurobiologie Hamburg, University of Hamburg, D-20249 Hamburg, Germany.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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