Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma.

Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Research Abstract Details 

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Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Abstract Text:

Xiao Z Shen,Ping Li,Daiana Weiss,Sebastien Fuchs,Hong D Xiao,Jon A Adams,Ifor R Williams,Mario R Capecchi,W Robert Taylor,Kenneth E Bernstein,

Angiotensin-converting enzyme (ACE) is a peptidase responsible for the cleavage of angiotensin I and several other peptides. Here, gene targeting was used to switch control of the ACE locus from the endogenous promoter to the macrophage-specific c-fms promoter. Challenge of these mice, called ACE 10/10, with the aggressive mouse melanoma cell line B16 showed that they are remarkably resistant to tumor growth. Tumor resistance was seen after challenge with different melanoma cell lines and in mice with different genetic backgrounds. Histological study of the tumors that did grow in ACE 10/10 mice showed an enhanced inflammatory response. ACE 10/10 mice had increased numbers of tumor epitope-specific CD8(+) T cells after challenge with melanoma or lymphoma. ACE 10/10 macrophages showed increased production of interleukin-12 and nitric oxide but reduced interleukin-10. Engraftment of wild-type mice with ACE 10/10 bone marrow transferred B16 tumor resistance. Injection of B16 tumors with ACE 10/10 macrophages also reduced tumor growth. ACE 10/10 mice may define a new means of enhancing the immune response, which may be potentially useful in several human clinical situations.

Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Publishing Authors By Initials

XZ Shen,P Li,D Weiss,S Fuchs,HD Xiao,JA Adams,IR Williams,MR Capecchi,WR Taylor,KE Bernstein,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research

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MEDLINE DATE:

Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of pathology

VOLUME: 170

Page Numbers: 2122-34

Journal Abbreviation: Am. J. Pathol.

ISSN: 0002-9440

DAY: 3

MONTH: Jun

YEAR: 2007

Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370502

Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Keywords Mesh Terms:

KEYWORDS: Tissue Distribution

MESH TERMS: pathology

Chemical & Substance for Abstract: Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma.

AFFILIATION: Department of Pathology and Laboratory Medicine, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R37 DK 039777

ACRONYM: DK

MEDLINETA: Am J Pathol

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