Methylphenidate infusion in euthymic bipolars: effect of carbamazepine pretreatment.

Methylphenidate infusion in euthymic bipolars: effect of carbamazepine pretreatment. Research Abstract Details 

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Methylphenidate infusion in euthymic bipolars: effect of carbamazepine pretreatment. Abstract Text:

A number of studies have reported attenuation by lithium (Li) pretreatment of the activating and euphoriant effects of psychostimulants. In view of increasing interest in the therapeutic potential of carbamazepine (CBZ) in bipolar disorder, we examined the effect of CBZ pretreatment on methylphenidate-induced behavioral activation and euphoria. Seven euthymic bipolar subjects received 2 weeks of pretreatment with CBZ or placebo in a double-blind crossover design. After each pretreatment period, the subjects received methylphenidate, 30 mg i.v.; mood and behavior changes were monitored for a period of 5 hours after each infusion. Methylphenidate induced a striking psychostimulant effect that was not attenuated by CBZ pretreatment. Possible implications of this finding for the antimanic efficacy of CBZ and for mechanisms of action are discussed.

Methylphenidate infusion in euthymic bipolars: effect of carbamazepine pretreatment. Publishing Authors By Initials

For similar therapeutics: drug therapy: premedication research abstracts see: therapeutics: drug therapy: premedication research

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Methylphenidate infusion in euthymic bipolars: effect of carbamazepine pretreatment. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Psychiatry research

VOLUME: 16

Page Numbers: 303-8

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 17

MONTH: Dec

YEAR: 1985

Methylphenidate infusion in euthymic bipolars: effect of carbamazepine pretreatment. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

Methylphenidate infusion in euthymic bipolars: effect of carbamazepine pretreatment. Keywords Mesh Terms:

KEYWORDS: Premedication

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Methylphenidate infusion in euthymic bipolars: effect of carbamazepine pretreatment. Information

Substance Name: Carbamazepine

Registry Number: 298-46-4

Grant and Affiliation Information for Methylphenidate infusion in euthymic bipolars: effect of carbamazepine pretreatment.

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Country: NETHERLANDS

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MEDLINETA: Psychiatry Res

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