Methylphenidate and cocaine: a placebo-controlled drug interaction study.

Methylphenidate and cocaine: a placebo-controlled drug interaction study. Research Abstract Details 

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Methylphenidate and cocaine: a placebo-controlled drug interaction study. Abstract Text:

Theresa Winhusen,Eugene Somoza,Bonita M Singal,Judy Harrer,Sandhya Apparaju,Juris Mezinskis,Pankaj Desai,Ahmed Elkashef,C Nora Chiang,Paul Horn,

Up to thirty percent of cocaine addicted individuals may meet diagnostic criteria for Attention-Deficit/Hyperactivity Disorder (ADHD). Methylphenidate (MPH) is a highly effective and commonly used treatment for ADHD but, like cocaine, is a cardiovascular and central nervous system stimulant with the potential to cause toxicity at high doses. The present study was undertaken to investigate the likelihood of a toxic reaction in individuals who use cocaine while concurrently taking MPH. Seven non-treatment seeking cocaine-dependent individuals completed this placebo-controlled, crossover study with two factors: Medication (placebo, 60 mg MPH, 90 mg MPH) and Infusion (saline, 20 mg cocaine, 40 mg cocaine). Physiological measures included vital signs, adverse events, and electrocardiogram. Subjective response was measured with visual analog scale (VAS) ratings of craving and drug effect. Cocaine pharmacokinetic parameters were calculated for each participant at each drug combination, using a non-compartmental model. MPH was well tolerated, did not have a clinically significant impact on cocaine's physiological effects, and decreased some of the positive subjective effects of cocaine. MPH did not significantly alter the pharmacokinetics of cocaine. The study results suggest that MPH at the doses studied can likely be used safely in an outpatient setting with active cocaine users.

Methylphenidate and cocaine: a placebo-controlled drug interaction study. Publishing Authors By Initials

T Winhusen,E Somoza,BM Singal,J Harrer,S Apparaju,J Mezinskis,P Desai,A Elkashef,CN Chiang,P Horn,

For similar pharmaceutical preparations: placebos research abstracts see: pharmaceutical preparations: placebos research

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Methylphenidate and cocaine: a placebo-controlled drug interaction study. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Pharmacology, biochemistry, and behavior

VOLUME: 85

Page Numbers: 29-38

Journal Abbreviation: Pharmacol. Biochem. Behav.

ISSN: 0091-3057

DAY: 17

MONTH: 08

YEAR: 2006

Methylphenidate and cocaine: a placebo-controlled drug interaction study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 367050

Methylphenidate and cocaine: a placebo-controlled drug interaction study. Keywords Mesh Terms:

KEYWORDS: Placebos

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Methylphenidate and cocaine: a placebo-controlled drug interaction study. Information

Substance Name: Cocaine

Registry Number: 50-36-2

Grant and Affiliation Information for Methylphenidate and cocaine: a placebo-controlled drug interaction study.

AFFILIATION: Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. winhusen@mdru.uc.edu

Country: United States

AGENCY: United States NIDA

GRANT: Y01 DA 50038-00

ACRONYM: DA

MEDLINETA: Pharmacol Biochem Behav

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