Methylmalonic acid values in healthy Dutch children.

Methylmalonic acid values in healthy Dutch children. Research Abstract Details 

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Methylmalonic acid values in healthy Dutch children. Abstract Text:

Marije Hogeveen,Ingrid van Beynum,Arno van Rooij,Leo Kluijtmans,Martin den Heijer,Henk Blom,

BACKGROUND: Plasma methylmalonic acid (MMA) is a specific marker for functional cobalamin deficiency. This deficiency can give rise to non-specific but serious symptoms in childhood such as developmental delay, convulsions and failure to thrive and may even lead to irreversible neurological damage. AIM OF THE STUDY: To analyse plasma MMA concentrations in Dutch children and to evaluate possible factors influencing its concentration. METHODS: A number of 186 Dutch children aged 0-19 years were analysed cross-sectionally. Blood was collected to measure MMA, total homocysteine (tHcy), cobalamin (Cbl) and serum creatinine concentrations. In addition, information about medical history, age and sex was recorded. RESULTS: The geometric mean (GM) plasma MMA concentration was 0.17 micromol/l (95% CI 0.07-0.42) and the GM tHcy was 6.6 micromol/l (95% CI 3.1-13.9). There is a slight positive correlation between plasma MMA and age in children >1 year (r = 0.211, P < 0.05). Plasma MMA concentrations were significantly higher in children with low Cbl concentrations. No significant difference in MMA, Cbl, tHcy or creatinine concentrations between sexes could be observed. Regression analysis showed that Cbl was the strongest determinant of plasma MMA (regression coefficient -0.414, P < 0.05). The association between MMA and Cbl is stronger at increasing age (P for trend 0.045). CONCLUSIONS: Plasma Cbl is the main determinant of MMA in this group of Dutch children. The strength of the association increased with increasing age.

Methylmalonic acid values in healthy Dutch children. Publishing Authors By Initials

M Hogeveen,I van Beynum,A van Rooij,L Kluijtmans,M den Heijer,H Blom,

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Methylmalonic acid values in healthy Dutch children. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of nutrition

VOLUME: 47

Page Numbers: 26-31

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ISSN: 1436-6207

DAY: 18

MONTH: 12

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Dept. of Paediatrics, Metabolic and Endocrine Diseases, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands, m.hogeveen@cukz.umcn.nl.

Country: Germany

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MEDLINETA: Eur J Nutr

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