Methodological issues in the assessment of substance use phenotypes.

Methodological issues in the assessment of substance use phenotypes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Methodological issues in the assessment of substance use phenotypes. Abstract Text:

Michael C Neale,Steven H Aggen,Hermine H Maes,Thomas S Kubarych,J Eric Schmitt,

The measurement of behavior is inherently problematic, and this is especially true of substance use and abuse phenotypes. The contingent nature of many assessments, such that symptoms of abuse and dependence cannot be obtained from those who have not initiated substance use, presents special difficulties. Furthermore, it is not clear whether individual differences in liability to use, abuse and dependence are best characterized as dimensions or classes or a combination of both. This article outlines research designs and methods suitable for quantifying liability to substance use. The value of data collected from relatives is emphasized in this context, as they permit identification of models normally compromised because data on, e.g., substance dependence symptoms, are systematically missing in those who have not initiated use of the substance in question.

Methodological issues in the assessment of substance use phenotypes. Publishing Authors By Initials

MC Neale,SH Aggen,HH Maes,TS Kubarych,JE Schmitt,

For similar disorders of environmental origin: substance-related disorders research abstracts see: disorders of environmental origin: substance-related disorders research

PUBMED ID PMID:

MEDLINE DATE:

Methodological issues in the assessment of substance use phenotypes. Journal Published:

PUBLICATION TYPE: Review

Journal: Addictive behaviors

VOLUME: 31

Page Numbers: 1010-34

Journal Abbreviation:

ISSN: 0306-4603

DAY: 24

MONTH: 05

YEAR: 2006

Methodological issues in the assessment of substance use phenotypes. Information

Number of References: 62

LANGUAGE: eng

NlmUniqueID: 7603486

Methodological issues in the assessment of substance use phenotypes. Keywords Mesh Terms:

KEYWORDS: Substance-Related Disorders

MESH TERMS: genetics

Chemical & Substance for Abstract: Methodological issues in the assessment of substance use phenotypes. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Methodological issues in the assessment of substance use phenotypes.

AFFILIATION: Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Box 980126, Richmond, VA 23298-0126, USA. neale@hsc.vcu.edu

Country: England

AGENCY: United States NCRR

GRANT: RR-08123

ACRONYM: RR

MEDLINETA: Addict Behav

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Methodological issues in the assessment of substance use phenotypes Related Publications

• ADCS Prevention Instrument Project: ADCS-clinicians' global impression of change scales (ADCS-CGIC), self-rated and study partner-rated versions.
• Assessing vaccine efficacy for the prevention of acute otitis media by pneumococcal vaccination in children: a methodological overview of statistical practice in randomized controlled clinical trials.
• Biomechanical and immunohistochemical analysis of high hydrostatic pressure-treated Achilles tendons.
• Chapter 22: Assuring the quality, safety and efficacy of HPV vaccines: The scientific basis of regulatory expectations pre- and post-licensure.
• Concomitant use of medications with anticholinergic properties and acetylcholinesterase inhibitors: impact on cognitive and physical functioning in Alzheimer disease.
• Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression.
• Disease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma.
• Effects of carrageenan and morphine on acute inflammation and pain in Lewis and Fischer rats.
• Effects of porcine bile on survival of Bacillus cereus vegetative cells and Haemolysin BL enterotoxin production in reconstituted human small intestine media.
• Efficacy of posaconazole and amphotericin B in experimental invasive pulmonary aspergillosis in dexamethasone immunosuppressed rats.
• Estimating the onset of cambial activity in Scots pine in northern Finland by means of the heat-sum approach.
• Force plate for measuring the ground reaction forces in small animal locomotion.
• Forelimb and hindlimb forces in walking and galloping primates.
• FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.
• Gynecological cytology: too old to be a pop star but too young to die.
• Hearing aid device that can be worn in the ear with a housing.
• Imatinib impairs the proliferation and function of CD4+CD25+ regulatory T cells in a dose-dependent manner.
• Immunohistochemical expression and distribution of VEGFR-3 in malignant mesothelioma.
• Immunohistochemical expression of VEGF-A and its ligands in non-neoplastic lesions of the breast sampling-assisted by dynamic angiothermography.
• Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix.
• Methodological issues in the assessment of substance use phenotypes.
• Prediction of lung cancer using volatile biomarkers in breath.
• Protection-based assays to measure aminoacyl-tRNA binding to translation initiation factors.
• Regulatory T cells--the renaissance of the suppressor T cells.
• Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment.
• The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.
• The association of pregnancy and the development of obesity - results of a systematic review and meta-analysis on the natural history of postpartum weight retention.
• The binding of advanced glycation end products to cell surfaces can be measured using bead-reconstituted cellular membrane proteins.
• The evolution of asymmetric genitalia in spiders and insects.
• [Cardiac imaging in clinical electrophysiology]