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Method for assessing the similarity between subsets of the T cell receptor repertoire.

Method for assessing the similarity between subsets of the T cell receptor repertoire. Research Abstract Details 

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  • Method for assessing the similarity between subsets of the T cell receptor repertoire. Abstract Text:

    vanessa venturiVanessa Venturi,katherine kedzierskaKatherine Kedzierska,mark m tanakaMark M Tanaka,stephen j turnerStephen J Turner,peter c dohertyPeter C Doherty,miles p davenportMiles P Davenport,

    The CD8(+) T cell response is important in the control of many viral and other infections. There have been many studies aimed at better understanding the influence of T cell receptor diversity on immune responses and the evolution of the T cell receptor repertoire over time and through the various stages of immune responses to infection. In recent years, there has been an increase in both the number of studies using T cell receptor data and the volume of T cell receptor data generated per study. Appropriate analytical tools are required to analyse this data. We present a robust approach to assessing the similarity between samples of the T cell receptor repertoire, which we demonstrate on published data of subsets of the influenza A virus D(b)NP(366)- and D(b)PA(224)-specific CD8(+) T cell responses in mice sorted on the expression of CD62L, which is a marker distinguishing central and effector memory cells.

    Method for assessing the similarity between subsets of the T cell receptor repertoire. Publishing Authors By Initials

    v venturiV Venturi,k kedzierskaK Kedzierska,mm tanakaMM Tanaka,sj turnerSJ Turner,pc dohertyPC Doherty,mp davenportMP Davenport,

    For similar abstracts research abstracts see: abstracts research

    PUBMED ID PMID:

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    Method for assessing the similarity between subsets of the T cell receptor repertoire. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Journal of immunological methods

    VOLUME: 329

    Page Numbers: 67-80

    Journal Abbreviation: J. Immunol. Methods

    ISSN: 0022-1759

    DAY: 29

    MONTH: 10

    YEAR: 2007

    Method for assessing the similarity between subsets of the T cell receptor repertoire. Information

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    LANGUAGE: eng

    NlmUniqueID: 1305440

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    Grant and Affiliation Information for Method for assessing the similarity between subsets of the T cell receptor repertoire.

    AFFILIATION: Department of Haematology, Prince of Wales Hospital, Kensington NSW 2052, Australia; Centre for Vascular Research, University of New South Wales, Kensington UNSW 2052, Australia.

    Country: Netherlands

    Netherlands Research PublicationNetherlands Research Publication

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    MEDLINETA: J Immunol Methods

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