Methamphetamine-induced neural and cognitive changes in rodents.

Methamphetamine-induced neural and cognitive changes in rodents. Research Abstract Details 

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Methamphetamine-induced neural and cognitive changes in rodents. Abstract Text:

John F Marshall,Annabelle M Belcher,Erin M Feinstein,Steven J O'Dell,

AIMS: Although psychostimulant drug abuse carries with it several potential health risks, the chronic abuse of amphetamines carries the danger of permanent brain injury. The purpose of these experiments is to develop animal models to understand the long-lasting influences of methamphetamine exposure on cerebral cortex and cognitive function. METHODS: The approach taken is to administer a regimen of methamphetamine known to be neurotoxic to dopamine and serotonin nerve terminals in the rat, and to investigate the influences of that dosing regimen on (i) cortical neuron integrity and function using anatomical stains and (ii) novel object recognition memory. RESULTS: In rodents, repeated administration of methamphetamine during a single day produces long-lasting damage to striatal dopamine and forebrain serotonin terminals as well as degeneration of somatosensory cortical neurons. The degeneration of somatosensory cortical neurons may represent only the most visible form of long-term deleterious effects on cerebral cortex, as exposure of rats to methamphetamine can reduce the immediate early gene responses of neurons in widespread cortical areas, even long after exposure to the drug. Together with the death and long-lasting functional impairments of cortical neurons, rats exposed to methamphetamine have impaired cognitive function. When tested for object recognition memory, methamphetamine-treated rats show deficiencies lasting for at least 3 weeks after drug exposure. CONCLUSIONS: Using a rodent model, these findings provide an avenue to study the cortical influences of methamphetamine and their cognitive sequelae.

Methamphetamine-induced neural and cognitive changes in rodents. Publishing Authors By Initials

JF Marshall,AM Belcher,EM Feinstein,SJ O'Dell,

For similar organic chemicals: amines: biogenic amines: biogenic monoamines: tryptamines: serotonin research abstracts see: organic chemicals: amines: biogenic amines: biogenic monoamines: tryptamines: serotonin research

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Methamphetamine-induced neural and cognitive changes in rodents. Journal Published:

PUBLICATION TYPE: Review

Journal: Addiction (Abingdon, England)

VOLUME: 102 Suppl 1

Page Numbers: 61-9

Journal Abbreviation: Addiction

ISSN: 0965-2140

DAY: 3

MONTH: Apr

YEAR: 2007

Methamphetamine-induced neural and cognitive changes in rodents. Information

Number of References: 63

LANGUAGE: eng

NlmUniqueID: 9304118

Methamphetamine-induced neural and cognitive changes in rodents. Keywords Mesh Terms:

KEYWORDS: Serotonin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Methamphetamine-induced neural and cognitive changes in rodents. Information

Substance Name: Methamphetamine

Registry Number: 537-46-2

Grant and Affiliation Information for Methamphetamine-induced neural and cognitive changes in rodents.

AFFILIATION: Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697-4550, USA. jfmarsha@uci.edu

Country: England

AGENCY: United States NIDA

GRANT: DA 48849

ACRONYM: DA

MEDLINETA: Addiction

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