Metformin promotes isolated rat liver mitochondria impairment.

Metformin promotes isolated rat liver mitochondria impairment. Research Abstract Details 

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Metformin promotes isolated rat liver mitochondria impairment. Abstract Text:

Cristina Carvalho, Correia,Maria S Santos,Raquel ,Catarina R Oliveira,Paula I Moreira,

Metformin, a drug widely used in the treatment of type 2 diabetes, has recently received attention due to the new and contrasting findings regarding its effects on mitochondrial function. In the present study, we evaluated the effect of metformin in isolated rat liver mitochondria status. We observed that metformin concentrations >/=8 mM induce an impairment of the respiratory chain characterized by a decrease in RCR and state 3 respiration. However, only metformin concentrations >/=10 mM affect the oxidative phosphorylation system by decreasing the mitochondrial transmembrane potential and increasing the repolarization lag phase. Moreover, our results show that metformin does not prevent H(2)O(2) production, neither protects against lipid peroxidation induced by the pro-oxidant pair ADP/Fe(2+). In addition, we observed that metformin exacerbates Ca(2+)-induced permeability transition pore opening by decreasing the capacity of mitochondria to accumulate Ca(2+ )and increasing the oxidation of thiol groups. Taken together, our results show that metformin can promote liver mitochondria injury predisposing to cell death.

Metformin promotes isolated rat liver mitochondria impairment. Publishing Authors By Initials

C Carvalho,S Correia,MS Santos,R ,CR Oliveira,PI Moreira,

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Metformin promotes isolated rat liver mitochondria impairment. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular and cellular biochemistry

VOLUME: 308

Page Numbers: 75-83

Journal Abbreviation: Mol. Cell. Biochem.

ISSN: 0300-8177

DAY: 2

MONTH: 10

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Zoology - Faculty of Sciences and Technology, University of Coimbra, Coimbra, 3000-354, Portugal.

Country: Netherlands

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MEDLINETA: Mol Cell Biochem

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