Metalloproteases as potential therapeutic targets in arthritis treatment.

Metalloproteases as potential therapeutic targets in arthritis treatment. Research Abstract Details 

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Metalloproteases as potential therapeutic targets in arthritis treatment. Abstract Text:

Andrew D Rowan,Gary J Litherland,Wang Hui,Jennifer M Milner,Andrew D Rowan,Gary J Litherland,Wang Hui,Jennifer M Milner,

Dysregulated proteolysis of the extracellular matrix of articular cartilage represents a unifying hallmark of the arthritides, and has been a target for therapeutic intervention for some time, although clinical efficacy has been elusive. Members of the 'A disintegrin and metalloprotease with thrombospondin motifs' and matrix metalloprotease families are considered to be collectively responsible for cartilage catabolism, such that inhibition of these activities is theoretically a highly attractive strategy for preventing further proteolytic damage. This review outlines the biology of these metalloproteases and what we have learnt from inhibition studies and transgenics, and highlights the important questions that this information raises for the future development of therapeutics directed towards metalloproteases for arthritis treatment.

Metalloproteases as potential therapeutic targets in arthritis treatment. Publishing Authors By Initials

AD Rowan,GJ Litherland,W Hui,JM Milner,AD Rowan,GJ Litherland,W Hui,JM Milner,

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Metalloproteases as potential therapeutic targets in arthritis treatment. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Expert opinion on therapeutic targets

VOLUME: 12

Page Numbers: 1-18

Journal Abbreviation: Expert Opin. Ther. Targets

ISSN: 1744-7631

DAY: 13

MONTH: Jan

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 101127833

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AFFILIATION: Newcastle University, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle-upon-Tyne, NE2 4HH, UK +44 0 191 222 8821 ; +44 0 191 222 5455 ; a.d.rowan@ncl.ac.uk.

Country: England

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MEDLINETA: Expert Opin Ther Targets

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