Metal nanoparticle pollutants interfere with pulmonary surfactant function in vitro.

Metal nanoparticle pollutants interfere with pulmonary surfactant function in vitro. Research Abstract Details 

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Metal nanoparticle pollutants interfere with pulmonary surfactant function in vitro. Abstract Text:

Mandeep Singh Bakshi,Lin Zhao,Ronald Smith,Fred Possmayer,Nils O Petersen,Mandeep Singh Bakshi,Lin Zhao,Ronald Smith,Fred Possmayer,Nils O Petersen,Mandeep Singh Bakshi,Lin Zhao,Ronald Smith,Fred Possmayer,Nils O Petersen,

Reported associations between air pollution and pulmonary and cardiovascular diseases prompted studies on the effects of gold nanoparticles (Au NP) on pulmonary surfactant function. Low levels (3.7 mol % Au/lipid, 0.98% wt/wt) markedly inhibited adsorption of a semisynthetic pulmonary surfactant (dipalmitoyl-phosphatidylcholine (DPPC)/palmitoyl-oleoyl-phosphatidylglycerol/surfactant protein B (SP-B); 70:30:1 wt %). Au NP also impeded the surfactant's ability to reduce surface tension (gamma) to low levels during film compression and to respread during film expansion. Transmission electron microscopy showed that Au NP generated by a seed-growth method were spherical with diameters of approximately 15 nm. Including palmitoyl-oleoyl-phosphatidylglycerol appeared to coat the NP with at least one lipid bilayer but did not affect NP shape or size. Similar overall observations occurred with dimyristoyl phosphatidylglycerol. Dipalmitoyl-phosphatidylglycerol was less effective in NP capping, although similar sized NP were formed. Including SP-B (1% wt/wt) appears to induce the formation of elongated strands of interacting threads with the fluid phosphatidylglycerols (PG). Including DPPC resulted in formation of aggregated, less spherical NP with a larger size distribution. With DPPC, strand formation due to SP-B was not observed. Agarose gel electrophoresis studies demonstrated that the aggregation induced by SP-B blocked migration of PG-coated NP. Migration was also influenced by the fluidity of the PGs. It is concluded that Au NP can interact with and sequester pulmonary surfactant phospholipids and, if inhaled from the atmosphere, could impede pulmonary surfactant function in the lung.

Metal nanoparticle pollutants interfere with pulmonary surfactant function in vitro. Publishing Authors By Initials

MS Bakshi,L Zhao,R Smith,F Possmayer,NO Petersen,MS Bakshi,L Zhao,R Smith,F Possmayer,NO Petersen,MS Bakshi,L Zhao,R Smith,F Possmayer,NO Petersen,

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Metal nanoparticle pollutants interfere with pulmonary surfactant function in vitro. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biophysical journal

VOLUME: 94

Page Numbers: 855-68

Journal Abbreviation: Biophys. J.

ISSN: 1542-0086

DAY: 21

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Obstetrics and Gynaecology, University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.

Country: United States

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MEDLINETA: Biophys J

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