Metal incorporation in modified PNA duplexes.

Metal incorporation in modified PNA duplexes. Research Abstract Details 

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Metal incorporation in modified PNA duplexes. Abstract Text:

Delia-Laura Popescu,Terry J Parolin,Catalina Achim,

Substitution of bipyridine for a nucleobase leads to modified peptide nucleic acid (PNA) single strands that are bridged in the presence of Ni2+ into a duplex containing a combination of hydrogen and coordinative bonds. CD experiments demonstrate that the duplex adopts a structure similar to that of an unmodified 10-bp PNA duplex, and UV melting experiments show a very sensitive dependence of the duplex stability on the substitution of a nucleobase pair with a pair of ligands or a metal-ligand alternative base pair.

Metal incorporation in modified PNA duplexes. Publishing Authors By Initials

DL Popescu,TJ Parolin,C Achim,

For similar investigative techniques: chemistry, analytical: photometry: spectrophotometry: spectrophotometry, ultraviolet research abstracts see: investigative techniques: chemistry, analytical: photometry: spectrophotometry: spectrophotometry, ultraviolet research

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Metal incorporation in modified PNA duplexes. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 125

Page Numbers: 6354-5

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 28

MONTH: May

YEAR: 2003

Metal incorporation in modified PNA duplexes. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Metal incorporation in modified PNA duplexes. Keywords Mesh Terms:

KEYWORDS: Spectrophotometry, Ultraviolet

MESH TERMS: chemistry

Chemical & Substance for Abstract: Metal incorporation in modified PNA duplexes. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Metal incorporation in modified PNA duplexes.

AFFILIATION: Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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