Metabolomic approach to evaluate the toxicological effects of nonylphenol with rat urine.

Metabolomic approach to evaluate the toxicological effects of nonylphenol with rat urine. Research Abstract Details 

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Metabolomic approach to evaluate the toxicological effects of nonylphenol with rat urine. Abstract Text:

Sang Hee Lee,Han Min Woo,Byung Hwa Jung,Jeongae Lee,Oh Seung Kwon,Hee Soo Pyo,Man Ho Choi,Bong Chul Chung,

Metabolomics has focused on toxicological applications to (1) understand the mechanisms of toxicity, (2) identify novel biomarkers of toxicity, and (3) provide in vivo assessment in animal models through simple and fast methods to date. The toxicological effects of nonylphenol (NP) were evaluated after intraperitoneal injection of rats with 0, 50, and 250 mg kg(-1) day(-1) NP for four consecutive days. In the nontargeted approach, different extraction conditions were introduced to investigate the effects of NP on rats through gas chromatography/mass spectrometry (GC/MS). The GC/MS data obtained were further analyzed with partial least-squares discriminant analysis to compare toxicological effects between control and treated groups. The targeted approach was also used in combination with GC/MS to quantify endocrine hormones and to identify possible biomarkers in rat urine under optimal extraction conditions. In addition, we considered the metabolic trajectory to examine the metabolite profiles and patterns related to steroid metabolism in rats that were treated with NP, considering both treatment amount and time. The data suggest that tetrahydrocorticosterone and 5alpha-tetrahydrocorticosterone are possible urinary biomarkers of NP-induced toxicity. This metabolomic approach is a promising tool to assist with screening in toxicological studies.

Metabolomic approach to evaluate the toxicological effects of nonylphenol with rat urine. Publishing Authors By Initials

SH Lee,HM Woo,BH Jung,J Lee,OS Kwon,HS Pyo,MH Choi,BC Chung,

For similar biological sciences: pharmacology: toxicology research abstracts see: biological sciences: pharmacology: toxicology research

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Metabolomic approach to evaluate the toxicological effects of nonylphenol with rat urine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Analytical chemistry

VOLUME: 79

Page Numbers: 6102-10

Journal Abbreviation: Anal. Chem.

ISSN: 0003-2700

DAY: 18

MONTH: 07

YEAR: 2007

Metabolomic approach to evaluate the toxicological effects of nonylphenol with rat urine. Information

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LANGUAGE: eng

NlmUniqueID: 370536

Metabolomic approach to evaluate the toxicological effects of nonylphenol with rat urine. Keywords Mesh Terms:

KEYWORDS: Toxicology

MESH TERMS: methods

Chemical & Substance for Abstract: Metabolomic approach to evaluate the toxicological effects of nonylphenol with rat urine. Information

Substance Name: tetrahydrocorticosterone

Registry Number: 68-42-8

Grant and Affiliation Information for Metabolomic approach to evaluate the toxicological effects of nonylphenol with rat urine.

AFFILIATION: Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea.

Country: United States

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MEDLINETA: Anal Chem

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