Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Abstract Text:

Akio Kihara,Susumu Mitsutake,Yukiko Mizutani,Yasuyuki Igarashi,

Sphingolipids are major lipid constituents of the eukaryotic plasma membrane. Without certain sphingolipids, cells and/or embryos cannot survive, indicating that sphingolipids possess important physiological functions that are not substituted for by other lipids. One such role may be signaling. Recent studies have revealed that some sphingolipid metabolites, such as long-chain bases (LCBs; sphingosine (Sph) in mammals), long-chain base 1-phosphates (LCBPs; sphingosine 1-phosphate (S1P) in mammals), ceramide (Cer), and ceramide 1-phosphate (C1P), act as signaling molecules. The addition of phosphate groups to LCB/Sph and Cer generates LCBP/S1P and C1P, respectively. These phospholipids exhibit completely different functions than those of their precursors. In this review, we describe recent advances in understanding the functions of LCBP/S1P and C1P in mammals and in the yeast Saccharomyces cerevisiae. Since LCB/Sph, LCBP/S1P, Cer, and C1P are mutually convertible, regulation of not only the total amount of the each lipid but also of the overall balance in cellular levels is important. Therefore, we describe in detail their metabolic pathways, as well as the genes involved in each reaction.

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Publishing Authors By Initials

A Kihara,S Mitsutake,Y Mizutani,Y Igarashi,

For similar organic chemicals: alcohols: amino alcohols: sphingosine research abstracts see: organic chemicals: alcohols: amino alcohols: sphingosine research

PUBMED ID PMID:

MEDLINE DATE:

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Journal Published:

PUBLICATION TYPE: Review

Journal: Progress in lipid research

VOLUME: 46

Page Numbers: 126-44

Journal Abbreviation:

ISSN: 0163-7827

DAY: 14

MONTH: 03

YEAR: 2007

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7900832

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Keywords Mesh Terms:

KEYWORDS: Sphingosine

MESH TERMS: metabolism

Chemical & Substance for Abstract: Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Information

Substance Name: sphingosine 1-phosphate

Registry Number: 26993-30-6

Grant and Affiliation Information for Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.

AFFILIATION: Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Nishi 6-Choume, Sapporo, Japan. kihara@pharm.hokudai.ac.jp

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Prog Lipid Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate Related Publications

• A case of primary erythermalgia, wintry hypothermia and encephalopathy.
• Anthraquinone polyamines: novel channel blockers of N-methyl-D: -aspartate receptors.
• Association between food mixing ability and mandibular movements during chewing of a wax cube.
• Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver.
• Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-60.
• Comparative studies of anthraquinone- and anthracene-tetraamines as blockers of N-methyl-D-aspartate receptors.
• Cyclin-dependent kinase inhibitors block erythrocyte invasion and intraerythrocytic development of Babesia bovis in vitro.
• Design, synthesis, and biological evaluation of tricyclic heterocycle-tetraamine conjugates as potent NMDA channel blockers.
• Development of Taqman-Based Real-Time PCR Assays for Diagnostic Detection of Babesia bovis and Babesia bigemina.
• Development of a multiplex loop-mediated isothermal amplification (mLAMP) method for the simultaneous detection of bovine Babesia parasites.
• Effect of adding cellulolytic bacterium on stable cellulose-degrading microbial community.
• Effect of peptidyl-tRNA on polyuridylate directed polypeptide synthesis.
• Expression of the oxidative stress-regulated transcription factor bach2 in differentiating neuronal cells.
• Galactosamine-induced acute liver injury in rats reduces hepatic alpha-tocopherol transfer protein production.
• Heme induces ubiquitination and degradation of the transcription factor Bach1.
• Influence of altered occlusal guidance on masticatory muscle activity during clenching.
• Involvement of a host erythrocyte sialic acid content in Babesia bovis infection.
• Kinetics of the ceramide kinase inhibitor K1, a suppressor of mast-cell activation.
• Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.
• Microbial population in the biomass adhering to supporting material in a packed-bed reactor degrading organic solid waste.
• Observation of vacuum-ultraviolet Kr(2)* laser oscillation pumped by a compact discharge device.
• Polyamines and protein synthesis. VII. Effect of spermine on the binding of polyuridylic acid to 30S ribosomal subunits.
• R17 RNA replicase. IV. Rifamycin sensitive component of the replicase.
• R17 RNA replicase. VI. A large scale preparation of R17 template RNA.
• Studies on salivary gland ribonucleases. II. Purification of ribonucleases from bovine submaxillary gland and the effects of polyamines on their activities.
• The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells.
• The promoter of mouse transcription repressor bach1 is regulated by Sp1 and trans-activated by Bach1.
• Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1/S1P1 receptor.
• [Comparative evaluation of absorbed dose and image quality in X-ray head CT scanning for hospital facilities in Gunma.]
• [The Relationship between Missing Occlusal Units and Oral Health-related Quality of Life in SDA Patients.]