Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest.

Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest. Research Abstract Details 

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Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest. Abstract Text:

H Fukuoka,M Kiriyama,Y Nishimura,M Higurashi,Y Suzuki,A Gunji,

Immobilization induces abnormal bone metabolism and rapid decalcification. Measurements of bone mineral content disclosed rapid decalcification, especially in lumbar vertebral and metacarpal bones in our short-term 20-day bed rest study. Many factors could contribute to the marked demineralization. The activities of osteoclasts and osteoblasts were studied by following serum levels of tartrate-resistant acid phosphatase and alkaline phosphatase, biomarkers for osteocyte activity. There were no alterations in these enzymes during bed rest. However, urinary excretion of pyridinium cross-links, resorption markers of bone matrix itself, increased by day 10 with subsequent decrease at day 20. So decalcification was induced without any relation to osteoclast activity. As cytokines strongly modulate the function of osteoclasts, peripheral monocyte release of interleukin 1 alpha and tumor necrosis factor alpha were assayed to determine the contribution to this rapid demineralization. Cytokines were released transiently by day 7 and later rapidly decreased. However, there was no correlation between cytokine release and bone matrix resorption.

Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest. Publishing Authors By Initials

H Fukuoka,M Kiriyama,Y Nishimura,M Higurashi,Y Suzuki,A Gunji,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta physiologica Scandinavica. Supplementum

VOLUME: 616

Page Numbers: 37-41

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ISSN: 0302-2994

DAY: 20

MONTH: 02

YEAR: 1994

Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest. Information

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LANGUAGE: eng

NlmUniqueID: 376307

Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: metabolism

Chemical & Substance for Abstract: Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest. Information

Substance Name: Acid Phosphatase

Registry Number: EC 3.1.3.2

Grant and Affiliation Information for Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest.

AFFILIATION: Department of Maternal and Child Health, University of Tokyo.

Country: ENGLAND

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MEDLINETA: Acta Physiol Scand Suppl

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