Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A.

Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Research Abstract Details 

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Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Abstract Text:

Neil B Ruderman,Asish K Saha,

The metabolic syndrome can be defined as a state of metabolic dysregulation characterized by insulin resistance, central obesity, and a predisposition to type 2 diabetes, dyslipidemia, premature atherosclerosis, and other diseases. An increasing body of evidence has linked the metabolic syndrome to abnormalities in lipid metabolism that ultimately lead to cellular dysfunction. We review here the hypothesis that, in many instances, the cause of these lipid abnormalities could be a dysregulation of the adenosine monophosphate-activated protein kinase (AMPK)/malonyl coenzyme A (CoA) fuel-sensing and signaling mechanism. Such dysregulation could be reflected by isolated increases in malonyl CoA or by concurrent changes in malonyl CoA and AMPK, both of which would alter intracellular fatty acid partitioning. The possibility is also raised that pharmacological agents and other factors that activate AMPK and/or decrease malonyl CoA could be therapeutic targets.

Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Publishing Authors By Initials

NB Ruderman,AK Saha,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Journal Published:

PUBLICATION TYPE: Review

Journal: Obesity (Silver Spring, Md.)

VOLUME: 14 Suppl 1

Page Numbers: 25S-33S

Journal Abbreviation: Obesity (Silver Spring)

ISSN: 1930-7381

DAY: 21

MONTH: Feb

YEAR: 2006

Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Information

Number of References: 70

LANGUAGE: eng

NlmUniqueID: 101264860

Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: metabolism

Chemical & Substance for Abstract: Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Information

Substance Name: AMP-activated protein kinases

Registry Number: EC 2.7.11.31

Grant and Affiliation Information for Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A.

AFFILIATION: Division of Endocrinology, Boston University Medical Center, Boston, MA 02118, USA. nrude@bumc.bu.edu

Country: United States

AGENCY: United States NHLBI

GRANT: P01-HL 08758-01

ACRONYM: HL

MEDLINETA: Obesity (Silver Spring)

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