Meta-analysis of genome-wide linkage studies in BMI and obesity.

Meta-analysis of genome-wide linkage studies in BMI and obesity. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Meta-analysis of genome-wide linkage studies in BMI and obesity. Abstract Text:

Catherine L Saunders,Benedetta D Chiodini,Pak Sham,Cathryn M Lewis,Victor Abkevich,Adebowale A Adeyemo,Mariza de Andrade,Rector Arya,Gerald S Berenson,John Blangero,Michael Boehnke,Ingrid B Borecki,Yvon C Chagnon,Wei Chen,Anthony G Comuzzie,Hong-Wen Deng,Ravindranath Duggirala,Mary F Feitosa,Philippe Froguel,Robert L Hanson,Johannes Hebebrand,Patricia Huezo-Dias,Ahmed H Kissebah,Weidong Li,Amy Luke,Lisa J Martin,Matthew Nash,Miina Ohman,Lyle J Palmer,Leena Peltonen,Markus Perola,R Arlen Price,Susan Redline,Sathanur R Srinivasan,Michael P Stern,Steven Stone,Heather Stringham,Stephen Turner,Cisca Wijmenga,David A Collier,Catherine L Saunders,Benedetta D Chiodini,Pak Sham,Cathryn M Lewis,Victor Abkevich,Adebowale A Adeyemo,Mariza de Andrade,Rector Arya,Gerald S Berenson,John Blangero,Michael Boehnke,Ingrid B Borecki,Yvon C Chagnon,Wei Chen,Anthony G Comuzzie,Hong-Wen Deng,Ravindranath Duggirala,Mary F Feitosa,Philippe Froguel,Robert L Hanson,Johannes Hebebrand,Patricia Huezo-Dias,Ahmed H Kissebah,Weidong Li,Amy Luke,Lisa J Martin,Matthew Nash,Miina Ohman,Lyle J Palmer,Leena Peltonen,Markus Perola,R Arlen Price,Susan Redline,Sathanur R Srinivasan,Michael P Stern,Steven Stone,Heather Stringham,Stephen Turner,Cisca Wijmenga,David A Collier,Catherine L Saunders,Benedetta D Chiodini,Pak Sham,Cathryn M Lewis,Victor Abkevich,Adebowale A Adeyemo,Mariza de Andrade,Rector Arya,Gerald S Berenson,John Blangero,Michael Boehnke,Ingrid B Borecki,Yvon C Chagnon,Wei Chen,Anthony G Comuzzie,Hong-Wen Deng,Ravindranath Duggirala,Mary F Feitosa,Philippe Froguel,Robert L Hanson,Johannes Hebebrand,Patricia Huezo-Dias,Ahmed H Kissebah,Weidong Li,Amy Luke,Lisa J Martin,Matthew Nash,Miina Ohman,Lyle J Palmer,Leena Peltonen,Markus Perola,R Arlen Price,Susan Redline,Sathanur R Srinivasan,Michael P Stern,Steven Stone,Heather Stringham,Stephen Turner,Cisca Wijmenga,David A Collier,

OBJECTIVE: The objective was to provide an overall assessment of genetic linkage data of BMI and BMI-defined obesity using a nonparametric genome scan meta-analysis. RESEARCH METHODS AND PROCEDURES: We identified 37 published studies containing data on over 31,000 individuals from more than >10,000 families and obtained genome-wide logarithm of the odds (LOD) scores, non-parametric linkage (NPL) scores, or maximum likelihood scores (MLS). BMI was analyzed in a pooled set of all studies, as a subgroup of 10 studies that used BMI-defined obesity, and for subgroups ascertained through type 2 diabetes, hypertension, or subjects of European ancestry. RESULTS: Bins at chromosome 13q13.2- q33.1, 12q23-q24.3 achieved suggestive evidence of linkage to BMI in the pooled analysis and samples ascertained for hypertension. Nominal evidence of linkage to these regions and suggestive evidence for 11q13.3-22.3 were also observed for BMI-defined obesity. The FTO obesity gene locus at 16q12.2 also showed nominal evidence for linkage. However, overall distribution of summed rank p values <0.05 is not different from that expected by chance. The strongest evidence was obtained in the families ascertained for hypertension at 9q31.1-qter and 12p11.21-q23 (p < 0.01). Conclusion: Despite having substantial statistical power, we did not unequivocally implicate specific loci for BMI or obesity. This may be because genes influencing adiposity are of very small effect, with substantial genetic heterogeneity and variable dependence on environmental factors. However, the observation that the FTO gene maps to one of the highest ranking bins for obesity is interesting and, while not a validation of this approach, indicates that other potential loci identified in this study should be investigated further.

Meta-analysis of genome-wide linkage studies in BMI and obesity. Publishing Authors By Initials

CL Saunders,BD Chiodini,P Sham,CM Lewis,V Abkevich,AA Adeyemo,M de Andrade,R Arya,GS Berenson,J Blangero,M Boehnke,IB Borecki,YC Chagnon,W Chen,AG Comuzzie,HW Deng,R Duggirala,MF Feitosa,P Froguel,RL Hanson,J Hebebrand,P Huezo-Dias,AH Kissebah,W Li,A Luke,LJ Martin,M Nash,M Ohman,LJ Palmer,L Peltonen,M Perola,RA Price,S Redline,SR Srinivasan,MP Stern,S Stone,H Stringham,S Turner,C Wijmenga,D A Collier,CL Saunders,BD Chiodini,P Sham,CM Lewis,V Abkevich,AA Adeyemo,M de Andrade,R Arya,GS Berenson,J Blangero,M Boehnke,IB Borecki,YC Chagnon,W Chen,AG Comuzzie,HW Deng,R Duggirala,MF Feitosa,P Froguel,RL Hanson,J Hebebrand,P Huezo-Dias,AH Kissebah,W Li,A Luke,LJ Martin,M Nash,M Ohman,LJ Palmer,L Peltonen,M Perola,RA Price,S Redline,SR Srinivasan,MP Stern,S Stone,H Stringham,S Turner,C Wijmenga,D A Collier,CL Saunders,BD Chiodini,P Sham,CM Lewis,V Abkevich,AA Adeyemo,M de Andrade,R Arya,GS Berenson,J Blangero,M Boehnke,IB Borecki,YC Chagnon,W Chen,AG Comuzzie,HW Deng,R Duggirala,MF Feitosa,P Froguel,RL Hanson,J Hebebrand,P Huezo-Dias,AH Kissebah,W Li,A Luke,LJ Martin,M Nash,M Ohman,LJ Palmer,L Peltonen,M Perola,RA Price,S Redline,SR Srinivasan,MP Stern,S Stone,H Stringham,S Turner,C Wijmenga,D A Collier,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Meta-analysis of genome-wide linkage studies in BMI and obesity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Obesity (Silver Spring, Md.)

VOLUME: 15

Page Numbers: 2263-75

Journal Abbreviation:

ISSN: 1930-7381

DAY: 24

MONTH: Sep

YEAR: 2007

Meta-analysis of genome-wide linkage studies in BMI and obesity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101264860

Meta-analysis of genome-wide linkage studies in BMI and obesity. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Meta-analysis of genome-wide linkage studies in BMI and obesity. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Meta-analysis of genome-wide linkage studies in BMI and obesity.

AFFILIATION: King's College London, Guy's, King's & St. Thomas' School of Medicine, London, United Kingdom.

Country: United States

AGENCY: United States NHLBI

GRANT: U10 HL54481

ACRONYM: HL

MEDLINETA: Obesity (Silver Spring)

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Meta-analysis of genome-wide linkage studies in BMI and obesity Related Publications

• Meta-analysis of genome-wide linkage studies in BMI and obesity.