Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity.

Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity. Research Abstract Details 

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Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity. Abstract Text:

Prokaryotic toxin-antitoxin (TA) loci consist of two genes in an operon that encodes a metabolically stable toxin and an unstable antitoxin. The antitoxin neutralizes its cognate toxin by forming a tight complex with it. In all cases known, the antitoxin autoregulates TA operon transcription by binding to one or more operators in the promoter region while the toxin functions as a co-repressor of transcription. Interestingly, the toxin can also stimulate TA operon transcription. Here we analyse mechanistic aspects of how RelE of Escherichia coli can function both as a co-repressor and as a derepressor of relBE transcription. When RelB was in excess to RelE, two trimeric RelB(2)*RelE complexes bound cooperatively to two adjacent operator sites in the relBE promoter region and repressed transcription. In contrast, RelE in excess stimulated relBE transcription and released the RelB(2)*RelE complex from operator DNA. A mutational analysis of the operator sites showed that RelE in excess counteracted cooperative binding of the RelB(2)*RelE complexes to the operator sites. Thus, RelE controls relBE transcription by conditional cooperativity.

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Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular microbiology

VOLUME: 69

Page Numbers: 841-57

Journal Abbreviation: Mol. Microbiol.

ISSN: 1365-2958

DAY: 4

MONTH: 06

YEAR: 2008

Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity. Information

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LANGUAGE: eng

NlmUniqueID: 8712028

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Grant and Affiliation Information for Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity.

AFFILIATION: Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.

Country: England

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MEDLINETA: Mol Microbiol

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