Mesenteric ischemia in giant cell arteritis: 6 cases and a systematic review.

Mesenteric ischemia in giant cell arteritis: 6 cases and a systematic review. Research Abstract Details 

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Mesenteric ischemia in giant cell arteritis: 6 cases and a systematic review. Abstract Text:

Pierre Sujobert,Laurence Fardet,Isabelle Marie,Pierre Duhaut,Pascal Cohen,Claire Grange,Jean-Baptiste Gaultier,Lionel ,Jean Cabane,

OBJECTIVE: To report the main features of mesenteric ischemia related to giant cell arteritis (GCA). METHODS: We screened 13 French internal medicine tertiary care centers for their cases of patients exhibiting GCA-associated mesenteric ischemia during a 16-year period (1990-2006). Patients were included if they reported newly developed abdominal symptoms associated with histological proof of GCA-associated mesenteric vasculitis and/or radiological abnormalities consistent with GCA-associated mesenteric vasculitis. We performed a Medline search to identify previously reported cases of GCA-associated mesenteric ischemia. RESULTS: We included 6 original cases and 22 cases identified in the literature (mean age of the 28 patients: 72.4 +/- 7.1 yrs; women: 79%). GCA was histologically proven for all patients. In 12 patients GCA diagnosis preceded mesenteric inflammatory arteritis. Mesenteric ischemia occurred either soon after initiation of steroid therapy (n = 6, mean time to onset after starting steroid 12 +/- 11 days) or with a low-dose steroid regimen (n = 6, dosage 0-10 mg/day). In 16 other patients, the mesenteric involvement was the first manifestation of GCA. Only 6 patients (21%) reported cardiovascular risk factors. Clinical manifestations of GCA-associated mesenteric ischemia, as well as biological markers (mean C-reactive protein level 91 +/- 50 mg/l), were very nonspecific. Imaging explorations were performed for 14 patients and showed specific signs of vasculitis on the mesenteric artery in 10 (71%). Nineteen patients (68%) required laparotomy and 9 patients (33%) died. CONCLUSION: Early diagnosis and medical management of mesenteric GCA may ameliorate the severe prognosis of this possibly underdiagnosed complication.

Mesenteric ischemia in giant cell arteritis: 6 cases and a systematic review. Publishing Authors By Initials

P Sujobert,L Fardet,I Marie,P Duhaut,P Cohen,C Grange,JB Gaultier,L ,J Cabane,

For similar diagnosis: prognosis research abstracts see: diagnosis: prognosis research

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Mesenteric ischemia in giant cell arteritis: 6 cases and a systematic review. Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of rheumatology

VOLUME: 34

Page Numbers: 1727-32

Journal Abbreviation: J. Rheumatol.

ISSN: 0315-162X

DAY: 1

MONTH: 07

YEAR: 2007

Mesenteric ischemia in giant cell arteritis: 6 cases and a systematic review. Information

Number of References: 54

LANGUAGE: eng

NlmUniqueID: 7501984

Mesenteric ischemia in giant cell arteritis: 6 cases and a systematic review. Keywords Mesh Terms:

KEYWORDS: Prognosis

MESH TERMS: blood supply

Chemical & Substance for Abstract: Mesenteric ischemia in giant cell arteritis: 6 cases and a systematic review. Information

Substance Name: C-Reactive Protein

Registry Number: 9007-41-4

Grant and Affiliation Information for Mesenteric ischemia in giant cell arteritis: 6 cases and a systematic review.

AFFILIATION: Department of Internal Medicine, Hôpital Saint-Antoine, Paris, France.

Country: Canada

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MEDLINETA: J Rheumatol

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