Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles.

Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles. Research Abstract Details 

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Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles. Abstract Text:

Brett Hall,Jennifer Dembinski,A Kate Sasser,Matus Studeny,Michael Andreeff,Frank Marini,

Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anti-cancer agents that blunt tumor growth kinetics and inhibit the growth of tumors in situ. In this review article, we describe the biological properties of MSC within the tumor microenvironment and discuss the potential use of MSC and other bone marrow-derived cell populations as delivery vehicles for antitumor proteins.

Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles. Publishing Authors By Initials

B Hall,J Dembinski,AK Sasser,M Studeny,M Andreeff,F Marini,

For similar neoplasms research abstracts see: neoplasms research

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Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles. Journal Published:

PUBLICATION TYPE: Review

Journal: International journal of hematology

VOLUME: 86

Page Numbers: 8-16

Journal Abbreviation: Int. J. Hematol.

ISSN: 0925-5710

DAY: 27

MONTH: Jul

YEAR: 2007

Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles. Information

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LANGUAGE: eng

NlmUniqueID: 9111627

Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles. Keywords Mesh Terms:

KEYWORDS: Neoplasms

MESH TERMS: therapy

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Grant and Affiliation Information for Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles.

AFFILIATION: Department of Pediatrics, The Ohio State University and Center for Childhood Cancer, Columbus Children's Research Institute, Columbus, OH, USA.

Country: United States

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MEDLINETA: Int J Hematol

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