Merotelic kinetochores in mammalian tissue cells.

Merotelic kinetochores in mammalian tissue cells. Research Abstract Details 

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Merotelic kinetochores in mammalian tissue cells. Abstract Text:

Merotelic kinetochore attachment is a major source of aneuploidy in mammalian tissue cells in culture. Mammalian kinetochores typically have binding sites for about 20-25 kinetochore microtubules. In prometaphase, kinetochores become merotelic if they attach to microtubules from opposite poles rather than to just one pole as normally occurs. Merotelic attachments support chromosome bi-orientation and alignment near the metaphase plate and they are not detected by the mitotic spindle checkpoint. At anaphase onset, sister chromatids separate, but a chromatid with a merotelic kinetochore may not be segregated correctly, and may lag near the spindle equator because of pulling forces toward opposite poles, or move in the direction of the wrong pole. Correction mechanisms are important for preventing segregation errors. There are probably more than 100 times as many PtK1 tissue cells with merotelic kinetochores in early mitosis, and about 16 times as many entering anaphase as the 1% of cells with lagging chromosomes seen in late anaphase. The role of spindle mechanics and potential functions of the Ndc80/Nuf2 protein complex at the kinetochore/microtubule interface is discussed for two correction mechanisms: one that functions before anaphase to reduce the number of kinetochore microtubules to the wrong pole, and one that functions after anaphase onset to move merotelic kinetochores based on the ratio of kinetochore microtubules to the correct versus incorrect pole.

Merotelic kinetochores in mammalian tissue cells. Publishing Authors By Initials

For similar proteins: nuclear proteins research abstracts see: proteins: nuclear proteins research

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Merotelic kinetochores in mammalian tissue cells. Journal Published:

PUBLICATION TYPE: Review

Journal: Philosophical transactions of the Royal Society of

VOLUME: 360

Page Numbers: 553-68

Journal Abbreviation: Philos. Trans. R. Soc. Lond.,

ISSN: 0962-8436

DAY: 29

MONTH: Mar

YEAR: 2005

Merotelic kinetochores in mammalian tissue cells. Information

Number of References: 79

LANGUAGE: eng

NlmUniqueID: 7503623

Merotelic kinetochores in mammalian tissue cells. Keywords Mesh Terms:

KEYWORDS: Nuclear Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Merotelic kinetochores in mammalian tissue cells. Information

Substance Name: Nuclear Proteins

Registry Number: 0

Grant and Affiliation Information for Merotelic kinetochores in mammalian tissue cells.

AFFILIATION: Department of Biology, 607 Fordham Hall, University of North Carolina, Chapel Hill, NC 27599-3280, USA. tsalmon@email.unc.edu

Country: England

AGENCY: United States NIGMS

GRANT: GM 24364

ACRONYM: GM

MEDLINETA: Philos Trans R Soc Lond B Biol

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