Merocyanine dyes with improved photostability.

Merocyanine dyes with improved photostability. Research Abstract Details 

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Merocyanine dyes with improved photostability. Abstract Text:

Alexei Toutchkine,Dan-Vinh Nguyen,Klaus M Hahn,

Merocyanine dyes have proven valuable for live cell fluorescence imaging applications, but many structures have been limited by rapid photobleaching. We show that photostability is substantially enhanced for merocyanines having a cyano group at a specific position in the central polymethine chain. Evidence is presented that this is due to reduction in reactivity of the dyes with singlet oxygen. These results point toward cyano-substitution as a general strategy for improving dye performance in imaging applications.

Merocyanine dyes with improved photostability. Publishing Authors By Initials

A Toutchkine,DV Nguyen,KM Hahn,

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: pyrimidines: pyrimidinones research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: pyrimidines: pyrimidinones research

PUBMED ID PMID:

MEDLINE DATE:

Merocyanine dyes with improved photostability. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Organic letters

VOLUME: 9

Page Numbers: 2775-7

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 21

MONTH: 06

YEAR: 2007

Merocyanine dyes with improved photostability. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100890393

Merocyanine dyes with improved photostability. Keywords Mesh Terms:

KEYWORDS: Pyrimidinones

MESH TERMS: chemistry

Chemical & Substance for Abstract: Merocyanine dyes with improved photostability. Information

Substance Name: merocyanine dye

Registry Number: 58823-12-4

Grant and Affiliation Information for Merocyanine dyes with improved photostability.

AFFILIATION: Department of Pharmacology and Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. alexei.toutchkine@sial.com

Country: United States

AGENCY: United States NIGMS

GRANT: GM64346

ACRONYM: GM

MEDLINETA: Org Lett

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