Menstrual cycle phase and responses to drugs of abuse in humans.

Menstrual cycle phase and responses to drugs of abuse in humans. Research Abstract Details 

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Menstrual cycle phase and responses to drugs of abuse in humans. Abstract Text:

Jolan M Terner,Harriet de Wit,

Researchers have recently become aware of the importance of including women in research, including drug abuse research. With this increased awareness has come an increased scientific interest in the potential influence of menstrual cycle phase on responses to drugs. In this review, we discuss recent studies that have examined subjective and physiological responses to drugs of abuse in relation to menstrual cycle phase. With most of the drugs reviewed, including alcohol, benzodiazepines, caffeine, marijuana, nicotine and opioids, responses to the drugs were not different were inconsistent across cycle phases. However, with psychomotor stimulant drugs, such as amphetamine and cocaine, responses to the drugs were greater during the follicular, compared to the luteal, phase of the cycle. These findings suggest that, consistent with certain pre-clinical findings, circulating levels of ovarian hormones influence the central effects of stimulant drugs in women. With other drugs, the evidence to date suggests that ovarian hormones have modest, if any, effects on responses to abused drugs. We discuss methodological issues relating to inclusion of women with regular menstrual cycles.

Menstrual cycle phase and responses to drugs of abuse in humans. Publishing Authors By Initials

JM Terner,H de Wit,

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Menstrual cycle phase and responses to drugs of abuse in humans. Journal Published:

PUBLICATION TYPE: Review

Journal: Drug and alcohol dependence

VOLUME: 84

Page Numbers: 1-13

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ISSN: 0376-8716

DAY: 18

MONTH: 01

YEAR: 2006

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LANGUAGE: eng

NlmUniqueID: 7513587

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Grant and Affiliation Information for Menstrual cycle phase and responses to drugs of abuse in humans.

AFFILIATION: Department of Psychiatry, The University of Chicago, 5841 S. Maryland Ave., MC 3077, Chicago, IL 60637, USA. jterner@yoda.bsd.uchicago.edu

Country: Ireland

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MEDLINETA: Drug Alcohol Depend

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