Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES).

Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES). Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES). Abstract Text:

BACKGROUND: In women, prenatal exposure to diethylstilbestrol (DES) is associated with adult reproductive dysfunction. The mouse model, which replicates many DES outcomes, suggests DES causes epigenetic alterations, which are transmissable to daughters of prenatally exposed animals. We report menstrual and reproductive characteristics in a unique cohort comprising daughters of women exposed prenatally to DES. METHODS: Menstrual and reproductive outcomes and baseline characteristics were assessed by mailed questionnaire in 793 women whose mothers had documented information regarding in utero DES exposure. RESULTS: Mean age at menarche was 12.6 years in both groups, but daughters of the exposed women attained menstrual regularization later (mean age of 16.2 years vs. 15.8 years; P = 0.05), and were more likely to report irregular menstrual periods, odds ratio (OR) = 1.54 [95% confidence interval (95% CI 1.02-2.32)]. A possible association between mothers' DES exposure and daughters' infertility was compatible with chance, age, and cohort adjusted OR = 2.19 (95% CI 0.95-5.07). We found limited evidence that daughters of the exposed had more adverse reproductive outcomes, but daughters of exposed women had fewer live births (1.6) than the unexposed (1.9) (P = 0.005). CONCLUSIONS: The high risk of reproductive dysfunction seen in women exposed to DES in utero was not observed in their daughters, but most women in our cohort have not yet attempted to start their families, and further follow-up is needed to assess their reproductive health. Our findings of menstrual irregularity and possible infertility in third-generation women are preliminary but compatible with speculation regarding transgenerational transmission of DES-related epigenetic alterations in humans.

Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES). Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES). Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: International journal of epidemiology

VOLUME: 35

Page Numbers: 862-8

Journal Abbreviation:

ISSN: 0300-5771

DAY: 24

MONTH: 05

YEAR: 2006

Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7802871

Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES). Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES). Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES).

AFFILIATION: Department of Community and Family Medicine, Dartmouth Medical School, and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA. Linda.Titus-Ernstoff@Dartmouth.edu

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Int J Epidemiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol DES Related Publications

• Aerosol dosimetry research needs.
• Bereavement, gender, and cyberspace: a content analysis of parents' memorials to their children.
• Breast cancer incidence, 1980-2006: combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status.
• Carcinoma of the epiglottis treated by surgical excision with operative technic.
• Community as a key to healing after the death of a child.
• Direct analysis of the extracellular proteome from two strains of Helicobacter pylori.
• Effect of stimulus bandwidth on auditory skills in normal-hearing and hearing-impaired children.
• Efficient in vitro amplification of chronic wasting disease PrPRES.
• Empowerment will improve patient safety.
• Etanercept therapy for severe plaque psoriasis in a patient who underwent a liver transplant.
• Exploring the underlying hormonal mechanisms of prenatal risk factors for breast cancer: a review and commentary.
• FOOD CONSERVATION AND THE WAR.
• High-risk benign breast lesions: current strategies in management.
• Identification and characterization of potential sources of worker exposure to carbon nanofibers during polymer composite laboratory operations.
• Look, no hands! Unconventional transcriptional activators in bacteria.
• Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES).
• Mortality in women given diethylstilbestrol during pregnancy.
• PUBLIC HEALTH ENGINEERING: SEWAGE SLUDEG.
• Patient safety and surgeons: why the resistance?
• Phorbol ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKC-independent pathway.
• Preeclampsia risk in women exposed in utero to diethylstilbestrol.
• Prenatal diethylstilbestrol exposure and risk of breast cancer.
• Shuttle lock release modification of a trans-tibial prosthesis with an obese client.
• Solar ultraviolet irradiation of human cornea, lens, and retina: equations of ocular irradiation.
• Surgeon Eddie L. Hoover, MD: Editor-in-Chief of the Journal of the National Medical Association from 2004 to present. Interview by George Dawson.
• The defining role of structure (including epitaxy) in the plausibility of homeopathy.
• Use of nisin-coated plastic films to control Listeria monocytogenes on vacuum-packaged cold-smoked salmon.
• Use of soy proteins in baked foods.
• Use of soy proteins in bakery products.
• Youth and chemical dependence.