Memory encoded throughout our bodies: molecular and cellular basis of tissue regeneration.

Memory encoded throughout our bodies: molecular and cellular basis of tissue regeneration. Research Abstract Details 

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Memory encoded throughout our bodies: molecular and cellular basis of tissue regeneration. Abstract Text:

When a sheep loses its tail, it cannot regenerate it in the manner of lizards. On the other hand, it is possible to clone mammals from somatic cells, showing that a complete developmental program is intact in a wounded sheep's tail the same way it is in a lizard. Thus, there is a requirement for more than only the presence of the entire genetic code in somatic cells for regenerative abilities. Thoughts like this have motivated us to assemble more than just a factographic synopsis on tissue regeneration. As a model, we review skin wound healing in chronological order, and when possible, we use that overview as a framework to point out possible mechanisms of how damaged tissues can restore their original structure. This article postulates the existence of tissue structural memory as a complex distributed homeostatic mechanism. We support such an idea by referring to an extremely fragmented literature base, trying to synthesize a broad picture of important principles of how tissues and organs may store information about their own structure for the purposes of regeneration. Selected developmental, surgical, and tissue engineering aspects are presented and discussed in the light of recent findings in the field.When a sheep loses its tail, it cannot regenerate it in the manner of lizards. On the other hand, it is possible to clone mammals from somatic cells, showing that a complete developmental program is intact in a wounded sheep's tail the same way it is in a lizard. Thus, there is a requirement for more than only the presence of the entire genetic code in somatic cells for regenerative abilities. Thoughts like this have motivated us to assemble more than just a factographic synopsis on tissue regeneration. As a model, we review skin wound healing in chronological order, and when possible, we use that overview as a framework to point out possible mechanisms of how damaged tissues can restore their original structure. This article postulates the existence of tissue structural memory as a complex distributed homeostatic mechanism. We support such an idea by referring to an extremely fragmented literature base, trying to synthesize a broad picture of important principles of how tissues and organs may store information about their own structure for the purposes of regeneration. Selected developmental, surgical, and tissue engineering aspects are presented and discussed in the light of recent findings in the field.

Memory encoded throughout our bodies: molecular and cellular basis of tissue regeneration. Publishing Authors By Initials

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Memory encoded throughout our bodies: molecular and cellular basis of tissue regeneration. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric research

VOLUME: 63

Page Numbers: 502-12

Journal Abbreviation: Pediatr. Res.

ISSN: 0031-3998

DAY: 22

MONTH: May

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for Memory encoded throughout our bodies: molecular and cellular basis of tissue regeneration.

AFFILIATION: Developmental Biology Program, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01GM055081

ACRONYM: GM

MEDLINETA: Pediatr Res

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