Memory complaints are related to Alzheimer disease pathology in older persons.

Memory complaints are related to Alzheimer disease pathology in older persons. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Memory complaints are related to Alzheimer disease pathology in older persons. Abstract Text:

L L Barnes,J A Schneider,P A Boyle,J L Bienias,D A Bennett,

OBJECTIVE: To study the relationship between Alzheimer disease (AD) pathology and memory complaints proximate to death. METHODS: A group of 90 older persons underwent detailed clinical evaluations and brain autopsy at death. The evaluations included administration of questions on subjective memory complaints and clinical classification of dementia and AD. On postmortem examination, neuritic plaques, diffuse plaques, and neurofibrillary tangles in tissue samples from five cortical regions were counted, and a summary measure of overall AD pathology was derived. In addition, amyloid load and tau tangles were quantified in eight regions. RESULTS: In multiple linear regression models adjusted for age, sex, and education, memory complaints were associated with AD pathology, including both amyloid and tau tangles. Subsequent analyses demonstrated that the relationship between memory complaints and AD pathology was present in those with and without dementia, and could not be explained by the potentially confounding effects of depressive symptoms or coexisting common chronic health problems. CONCLUSION: Memory complaints in older persons may indicate self awareness of a degenerative process.

Memory complaints are related to Alzheimer disease pathology in older persons. Publishing Authors By Initials

LL Barnes,JA Schneider,PA Boyle,JL Bienias,DA Bennett,

For similar epidemiologic factors: sex factors research abstracts see: epidemiologic factors: sex factors research

PUBMED ID PMID:

MEDLINE DATE:

Memory complaints are related to Alzheimer disease pathology in older persons. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurology

VOLUME: 67

Page Numbers: 1581-5

Journal Abbreviation: Neurology

ISSN: 1526-632X

DAY: 14

MONTH: Nov

YEAR: 2006

Memory complaints are related to Alzheimer disease pathology in older persons. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 401060

Memory complaints are related to Alzheimer disease pathology in older persons. Keywords Mesh Terms:

KEYWORDS: Sex Factors

MESH TERMS: pathology

Chemical & Substance for Abstract: Memory complaints are related to Alzheimer disease pathology in older persons. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Memory complaints are related to Alzheimer disease pathology in older persons.

AFFILIATION: Rush Alzheimer's Disease Center, Rush University Medical Center, Armour Academic Facility, 600 S. Paulina, Suite 1038, Chicago, IL 60612, USA. lbarnes1@rush.edu

Country: United States

AGENCY: United States NIA

GRANT: R01AG22018

ACRONYM: AG

MEDLINETA: Neurology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Memory complaints are related to Alzheimer disease pathology in older persons Related Publications

• Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb.
• Body mass index in older persons is associated with Alzheimer disease pathology.
• Change in motor function and risk of mortality in older persons.
• Chronic psychological distress and risk of Alzheimer's disease in old age.
• Cognitive decline in old age: separating retest effects from the effects of growing older.
• Diabetes is related to cerebral infarction but not to AD pathology in older persons.
• Diabetes mellitus, dementia, and cognitive function in older persons.
• Discriminating inhalational anthrax from community-acquired pneumonia using chest radiograph findings and a clinical algorithm.
• Effects of aquatic exercise on flexibility, strength and aerobic fitness in adults with osteoarthritis of the hip or knee.
• Elder abuse.
• Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells.
• Experimental evidence for a metallohydrolase mechanism in which the nucleophile is not delivered by a metal ion: EPR spectrokinetic and structural studies of aminopeptidase from Vibrio proteolyticus.
• Genetic and environmental factors associated with incidence of infectious bovine keratoconjunctivitis in preweaned beef calves.
• Harm avoidance and disability in old age.
• Imaging oxygen pressure in the rodent retina by phosphorescence lifetime.
• In cis autosomal dominant mutation of Senataxin associated with tremor/ataxia syndrome.
• Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating.
• Loneliness and risk of Alzheimer disease.
• Memory complaints are related to Alzheimer disease pathology in older persons.
• Memory for facial expressions: the power of a smile.
• Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer disease.
• Personality and incident disability in older persons.
• Physical activity and motor decline in older persons.
• Physical activity is associated with incident disability in community-based older persons.
• Plant genome values: how much do we know?
• Postmortem indices linking risk factors to cognition: results from the Religious Order Study and the Memory and Aging Project.
• Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance.
• Serotonin facilitates a persistent calcium current in motoneurons of rats with and without chronic spinal cord injury.
• The GLH proteins, Caenorhabditis elegans P granule components, associate with CSN-5 and KGB-1, proteins necessary for fertility, and with ZYX-1, a predicted cytoskeletal protein.
• Unusual skin and testicular lesions in a patient with CMML.