Memory CD8+ T Cells Protect Dendritic Cells from CTL Killing.

Memory CD8+ T Cells Protect Dendritic Cells from CTL Killing. Research Abstract Details 

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Memory CD8+ T Cells Protect Dendritic Cells from CTL Killing. Abstract Text:

CD8(+) T cells have been shown to be capable of either suppressing or promoting immune responses. To reconcile these contrasting regulatory functions, we compared the ability of human effector and memory CD8(+) T cells to regulate survival and functions of dendritic cells (DC). We report that, in sharp contrast to the effector cells (CTLs) that kill DCs in a granzyme B- and perforin-dependent mechanism, memory CD8(+) T cells enhance the ability of DCs to produce IL-12 and to induce functional Th1 and CTL responses in naive CD4(+) and CD8(+) T cell populations. Moreover, memory CD8(+) T cells that release the DC-activating factor TNF-alpha before the release of cytotoxic granules induce DC expression of an endogenous granzyme B inhibitor PI-9 and protect DCs from CTL killing with similar efficacy as CD4(+) Th cells. The currently identified DC-protective function of memory CD8(+) T cells helps to explain the phenomenon of CD8(+) T cell memory, reduced dependence of recall responses on CD4(+) T cell help, and the importance of delayed administration of booster doses of vaccines for the optimal outcome of immunization.

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Memory CD8+ T Cells Protect Dendritic Cells from CTL Killing. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 180

Page Numbers: 3857-65

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Mar

YEAR: 2008

Memory CD8+ T Cells Protect Dendritic Cells from CTL Killing. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

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Grant and Affiliation Information for Memory CD8+ T Cells Protect Dendritic Cells from CTL Killing.

AFFILIATION: Department of Surgery.

Country: United States

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MEDLINETA: J Immunol

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