Memory and perseveration on a win-stay, lose-shift task in rats exposed neonatally to alcohol.

Memory and perseveration on a win-stay, lose-shift task in rats exposed neonatally to alcohol. Research Abstract Details 

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Memory and perseveration on a win-stay, lose-shift task in rats exposed neonatally to alcohol. Abstract Text:

Matthew C Bell,Edward P Riley,

OBJECTIVE: It is important to understand the relationship between perseverative responding resulting from perinatal exposure to alcohol and potential underlying causes, including attention, memory, or response-inhibition problems. The present study was designed to examine the relationship between perseveration and memory. METHOD: Rats exposed neonatally to 6 g/kg/day alcohol from postnatal day (PD) 4 through PD 9 using an artificial rearing technique (n = 8) were compared with an artificially reared gastrostomy control group (n = 8) and a suckle control group (n = 8). Activity levels were assessed from PD 18-21. Beginning on PD 45, subjects were deprived of food and responded for food on a two-lever win-stay, lose-shift task in which reinforcement probability was a function of reinforcement delivery on the previous trial. If reinforcement was delivered, only a response on the same lever (stay) was reinforced. If reinforcement was not delivered, only a response on the opposite lever (shift) was reinforced. Effective responding depended on subjects remembering whether a reinforcer was delivered on the preceding trial. The intertrial interval varied across conditions (5 seconds or 60 seconds). RESULTS: Alcohol-exposed rats showed increased activity during activity testing but did not differ from controls on win-stay, lose-shift accuracy. All groups showed a performance decrease at longer intertrial intervals. Alcohol-exposed rats showed increased lever pressing during the intertrial interval compared with suckle control rats but not with gastrostomy control rats. CONCLUSIONS: Choice behavior was comparable for all groups on the win-stay, lose-shift task, indicating that memory, as assessed by this task, was not differentially affected by alcohol exposure. Alcohol-exposed rats responded more during the intertrial interval compared with suckle controls, suggesting increased activity without increased response inhibition. The win-stay, lose-shift procedure is a potentially useful tool for separating simple activity level effects, memory-related effects, and response-inhibition effects. This study also highlights the need for additional research describing the relationship between perseverative responding and underlying mechanisms.

Memory and perseveration on a win-stay, lose-shift task in rats exposed neonatally to alcohol. Publishing Authors By Initials

MC Bell,EP Riley,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Memory and perseveration on a win-stay, lose-shift task in rats exposed neonatally to alcohol. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of studies on alcohol

VOLUME: 67

Page Numbers: 851-60

Journal Abbreviation: J. Stud. Alcohol

ISSN: 0096-882X

DAY: 3

MONTH: Nov

YEAR: 2006

Memory and perseveration on a win-stay, lose-shift task in rats exposed neonatally to alcohol. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503813

Memory and perseveration on a win-stay, lose-shift task in rats exposed neonatally to alcohol. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: drug effects

Chemical & Substance for Abstract: Memory and perseveration on a win-stay, lose-shift task in rats exposed neonatally to alcohol. Information

Substance Name: Ethanol

Registry Number: 64-17-5

Grant and Affiliation Information for Memory and perseveration on a win-stay, lose-shift task in rats exposed neonatally to alcohol.

AFFILIATION: Psychology Department, Santa Clara University, 500 El Camino Real, Santa Clara, California 95053, USA. mbell@scu.edu

Country: United States

AGENCY: United States NIAAA

GRANT: AA06902

ACRONYM: AA

MEDLINETA: J Stud Alcohol

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