Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis.

Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis. Research Abstract Details 

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Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis. Abstract Text:

H Sato,M Seiki,

Activated gelatinase A is reportedly associated with tumor spread. We identified novel matrix metalloproteinases that localize on the cell surface and mediate the activation of progelatinase A. Thus, these progelatinase A activators were named membrane-type matrix metalloproteinase-1 and -2 (MT-MMP-1 and -2, respectively). MT-MMP-1 is overexpressed in malignant tumor tissues, including lung and stomach carcinomas that contain activated gelatinase A. This suggests that MT-MMP-1 is associated with the activation of progelatinase A in these tumor tissues. The expression of MT-MMP-1 also induced binding of gelatinase A to the cell surface by functioning as a receptor. The cell surface localization of proteinases has advantages over pericellular proteolysis. MT-MMP-1 and its family may play a central role in the cell surface localization and activation of progelatinase A and via this mechanism, tumor cell use exogenous progelatinase A to mediate the proteolysis associated with invasion and metastasis.

Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis. Publishing Authors By Initials

H Sato,M Seiki,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research

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Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of biochemistry

VOLUME: 119

Page Numbers: 209-15

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Feb

YEAR: 1996

Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis. Information

Number of References: 36

LANGUAGE: eng

NlmUniqueID: 376600

Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis. Keywords Mesh Terms:

KEYWORDS: Sequence Homology, Amino Acid

MESH TERMS: metabolism

Chemical & Substance for Abstract: Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis. Information

Substance Name: Matrix Metalloproteinase 1

Registry Number: EC 3.4.24.7

Grant and Affiliation Information for Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis.

AFFILIATION: Department of Molecular Virology and Oncology, Kanazawa University.

Country: JAPAN

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MEDLINETA: J Biochem

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