Membrane remodeling from N-BAR domain interactions: insights from multi-scale simulation.

Membrane remodeling from N-BAR domain interactions: insights from multi-scale simulation. Research Abstract Details 

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Membrane remodeling from N-BAR domain interactions: insights from multi-scale simulation. Abstract Text:

Gary S Ayton,Philip D Blood,Gregory A Voth,

Liposome remodeling processes (e.g., vesiculation and tubulation) due to N-BAR domain interactions with the lipid bilayer are explored with a multi-scale simulation approach. Results from atomistic-level molecular dynamics simulations of membrane binding to the concave face of N-BAR domains are used along with discretized mesoscopic field-theoretic simulations to examine how the spontaneous curvature fields generated by N-BAR domains result in membrane remodeling. It is found that tubulation can be generated by anisotropic N-BAR spontaneous curvature fields, whereas vesiculation is only observed with isotropic N-BAR spontaneous curvature fields at high density. The results of the multi-scale simulations provide insight into recent experimental observations.

Membrane remodeling from N-BAR domain interactions: insights from multi-scale simulation. Publishing Authors By Initials

GS Ayton,PD Blood,GA Voth,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation: protein structure, tertiary research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation: protein structure, tertiary research

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MEDLINE DATE:

Membrane remodeling from N-BAR domain interactions: insights from multi-scale simulation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biophysical journal

VOLUME: 92

Page Numbers: 3595-602

Journal Abbreviation:

ISSN: 0006-3495

DAY: 26

MONTH: 02

YEAR: 2007

Membrane remodeling from N-BAR domain interactions: insights from multi-scale simulation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370626

Membrane remodeling from N-BAR domain interactions: insights from multi-scale simulation. Keywords Mesh Terms:

KEYWORDS: Protein Structure, Tertiary

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Membrane remodeling from N-BAR domain interactions: insights from multi-scale simulation. Information

Substance Name: amphiphysin

Registry Number: 147954-52-7

Grant and Affiliation Information for Membrane remodeling from N-BAR domain interactions: insights from multi-scale simulation.

AFFILIATION: Center for Biophysical Modeling and Simulation, University of Utah, Salt Lake City, Utah, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: 5 R01 GM063796

ACRONYM: GM

MEDLINETA: Biophys J

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