Membrane electroporation: The absolute rate equation and nanosecond time scale pore creation.

Membrane electroporation: The absolute rate equation and nanosecond time scale pore creation. Research Abstract Details 

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Membrane electroporation: The absolute rate equation and nanosecond time scale pore creation. Abstract Text:

Zlatko Vasilkoski,Axel T Esser,T R Gowrishankar,James C Weaver,

The recent applications of nanosecond, megavolt-per-meter electric field pulses to biological systems show striking cellular and subcellular electric field induced effects and revive the interest in the biophysical mechanism of electroporation. We first show that the absolute rate theory, with experimentally based parameter input, is consistent with membrane pore creation on a nanosecond time scale. Secondly we use a Smoluchowski equation-based model to formulate a self-consistent theoretical approach. The analysis is carried out for a planar cell membrane patch exposed to a 10 ns trapezoidal pulse with 1.5 ns rise and fall times. Results demonstrate reversible supraelectroporation behavior in terms of transmembrane voltage, pore density, membrane conductance, fractional aqueous area, pore distribution, and average pore radius. We further motivate and justify the use of Krassowska's asymptotic electroporation model for analyzing nanosecond pulses, showing that pore creation dominates the electrical response and that pore expansion is a negligible effect on this time scale.

Membrane electroporation: The absolute rate equation and nanosecond time scale pore creation. Publishing Authors By Initials

Z Vasilkoski,AT Esser,TR Gowrishankar,JC Weaver,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Membrane electroporation: The absolute rate equation and nanosecond time scale pore creation. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Physical review. E, Statistical, nonlinear, and so

VOLUME: 74

Page Numbers: 021904

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ISSN: 1539-3755

DAY: 3

MONTH: 08

YEAR: 2006

Membrane electroporation: The absolute rate equation and nanosecond time scale pore creation. Information

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LANGUAGE: eng

NlmUniqueID: 101136452

Membrane electroporation: The absolute rate equation and nanosecond time scale pore creation. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: radiation effects

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Grant and Affiliation Information for Membrane electroporation: The absolute rate equation and nanosecond time scale pore creation.

AFFILIATION: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01-GM63857

ACRONYM: GM

MEDLINETA: Phys Rev E Stat Nonlin Soft Ma

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