Melophlins p, q, R, and s: four new tetramic Acid derivatives, from two palauan marine sponges of the genus melophlus.

Melophlins p, q, R, and s: four new tetramic Acid derivatives, from two palauan marine sponges of the genus melophlus. Research Abstract Details 

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Melophlins p, q, R, and s: four new tetramic Acid derivatives, from two palauan marine sponges of the genus melophlus. Abstract Text:

Jinzhong Xu,Masateru Hasegawa,Ken-Ichi Harada,Hisayoshi Kobayashi,Hiroshi Nagai,Michio Namikoshi,

Four new tetramic acid derivatives, named melophlins P, Q, R, and S (1-4), were isolated from two marine sponges of the genus Melophlus collected at Palau, together with seven known melophlins A, D, E, G, H, I, and O. The structures of the new compounds were elucidated on the basis of their spectral data. The absolute stereochemistries at the tetramic acid moieties of the new compounds were determined as 1 : 1 mixtures (racemic) by ESI-LC/MS analysis of derivatives obtained by oxidation and hydrolysis of the respective parent compounds. Melophlins P-S (1-4) showed cytotoxicity against the murine leukemia cell line L1210 with IC(50) values of 20.0, 10.5, 0.85, and 5.13 muM, respectively.

Melophlins p, q, R, and s: four new tetramic Acid derivatives, from two palauan marine sponges of the genus melophlus. Publishing Authors By Initials

J Xu,M Hasegawa,K Harada,H Kobayashi,H Nagai,M Namikoshi,

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Melophlins p, q, R, and s: four new tetramic Acid derivatives, from two palauan marine sponges of the genus melophlus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Chemical & pharmaceutical bulletin

VOLUME: 54

Page Numbers: 852-4

Journal Abbreviation: Chem. Pharm. Bull.

ISSN: 0009-2363

DAY: 6

MONTH: Jun

YEAR: 2006

Melophlins p, q, R, and s: four new tetramic Acid derivatives, from two palauan marine sponges of the genus melophlus. Information

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LANGUAGE: eng

NlmUniqueID: 377775

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Chemical & Substance for Abstract: Melophlins p, q, R, and s: four new tetramic Acid derivatives, from two palauan marine sponges of the genus melophlus. Information

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Grant and Affiliation Information for Melophlins p, q, R, and s: four new tetramic Acid derivatives, from two palauan marine sponges of the genus melophlus.

AFFILIATION: Department of Ocean Sciences, Tokyo University of Marine Science and Technology.

Country: Japan

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MEDLINETA: Chem Pharm Bull (Tokyo)

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