Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line.

Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line. Abstract Text:

F Luchetti,B Canonico,F Mannello,C Masoni,A D'Emilio,M Battistelli,S Papa,E Falcieri,

Cardiolipin (CL) is found exclusively in the inner mitochondrial membrane. CL deficiency leads to an alteration in the stability of mitochondrial membranes, to an increased permeability as well as a decreased respiratory rate, and therefore to mitochondria which are completely dysfunctional. It is known that reactive oxygen species (ROS) cause a decrease and a variation in CL content, concomitantly the formation of the mitochondrial permeability transition pore facilitates the release of cytochrome c (cyt c) into the cytosol. Melatonin (Mel), the secretory product of the pineal gland, is a potent and efficient endogenous radical scavenger. It has been shown to protect, various biomolecules, such as DNA, membrane lipids, and cytosolic proteins from oxidative damage. To evaluate the protective role of Mel, we have studied U937 cells treated with UV-B irradiation. In our model, the administration of 1mM Mel before UV-B irradiation showed a significant protection from apoptotic cell death, in particular, mitochondrial structure and function were preserved through apoptotic pathways when cells were preincubated with 1mM Mel before UV-B exposure. The cardiolipin-sensitive probe 10-nonyl acridine orange (NAO) was used to monitor changes in mitochondrial lipids. Our data suggest that the Mel treatment protects CL from ROS and this suggests a possible link with the reduction of the apoptotic phenomenon.

Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line. Publishing Authors By Initials

F Luchetti,B Canonico,F Mannello,C Masoni,A D'Emilio,M Battistelli,S Papa,E Falcieri,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Toxicology in vitro : an international journal pub

VOLUME: 21

Page Numbers: 293-301

Journal Abbreviation:

ISSN: 0887-2333

DAY: 5

MONTH: 09

YEAR: 2006

Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8712158

Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line.

AFFILIATION: Istituto di Scienze Morfologiche, Università degli Studi di Urbino "Carlo Bo" Urbino, Italy.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Toxicol In Vitro

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line Related Publications

• C2C12 murine myoblasts as a model of skeletal muscle development: morpho-functional characterization.
• Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line.
• Morpho-functional changes in human tendon tissue.
• Morphometric and functional study of apoptotic cell chromatin.
• Surface and inner cell behaviour along skeletal muscle cell in vitro differentiation.