Melatonin modulates glycine currents of retinal ganglion cells in rat.

Melatonin modulates glycine currents of retinal ganglion cells in rat. Research Abstract Details 

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Melatonin modulates glycine currents of retinal ganglion cells in rat. Abstract Text:

Min Zhang,Li-Hui Cao,Xiong-Li Yang,Min Zhang,Li-Hui Cao,Xiong-Li Yang,Min Zhang,Li-Hui Cao,Xiong-Li Yang,

Melatonin is a hormone participating in the modulation of various physiological functions via binding to specific melatonin receptors. In the retina, melatonin is synthesized and released by photoreceptors and may play a neuromodulatory role. By using patch clamp techniques, we demonstrate for the first time that glycine-induced currents from a population of isolated ganglion cells in the rat retina are potentiated by melatonin of nanomolar concentrations by increasing the efficacy and the channel conductance of the strychnine-sensitive glycine receptor. The melatonin effect is blocked by 4-P-PDOT, indicating the mediation of the MT2 receptor. These results suggest that melatonin, along with the MT2 receptor, may be involved in retinal information processing by modulating glycine receptor-mediated inhibition.

Melatonin modulates glycine currents of retinal ganglion cells in rat. Publishing Authors By Initials

M Zhang,LH Cao,XL Yang,M Zhang,LH Cao,XL Yang,M Zhang,LH Cao,XL Yang,

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Melatonin modulates glycine currents of retinal ganglion cells in rat. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuroreport

VOLUME: 18

Page Numbers: 1675-8

Journal Abbreviation: Neuroreport

ISSN: 0959-4965

DAY: 29

MONTH: Oct

YEAR: 2007

Melatonin modulates glycine currents of retinal ganglion cells in rat. Information

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LANGUAGE: eng

NlmUniqueID: 9100935

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AFFILIATION: Institute of Neurobiology, Fudan University, Shanghai, P.R. China.

Country: England

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MEDLINETA: Neuroreport

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