Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III beta-tubulin levels.

Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III beta-tubulin levels. Research Abstract Details 

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Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III beta-tubulin levels. Abstract Text:

Nizar M Mhaidat,Rick F Thorne,Charles Edo de Bock,Xu Dong Zhang,Peter Hersey,Nizar M Mhaidat,Rick F Thorne,Charles Edo de Bock,Xu Dong Zhang,Peter Hersey,

We have previously shown that Docetaxel-induced variable degrees of apoptosis in melanoma. In this report, we studied the beta-tubulin repertoire of melanoma cell lines and show that class III beta-tubulin expression correlated with Docetaxel-resistance. Sensitive cells showed low levels of class III beta-tubulin with little microtubular incorporation, whereas class III beta-tubulin expression was higher in resistant cells and was incorporated into the cytoskeleton. As proof of concept, abrogation of class III by siRNA reverted Docetaxel-resistant cells to a sensitive phenotype, restoring the microtubular polymerisation response and promoting high levels of apoptosis through Bax activation. These results suggest that phenotypic expression of beta-tubulin class III in melanoma may help identify patients with melanoma that can respond to taxanes.

Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III beta-tubulin levels. Publishing Authors By Initials

NM Mhaidat,RF Thorne,CE de Bock,XD Zhang,P Hersey,NM Mhaidat,RF Thorne,CE de Bock,XD Zhang,P Hersey,

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Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III beta-tubulin levels. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: FEBS letters

VOLUME: 582

Page Numbers: 267-72

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 18

MONTH: 12

YEAR: 2007

Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III beta-tubulin levels. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III beta-tubulin levels.

AFFILIATION: Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan.

Country: Netherlands

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MEDLINETA: FEBS Lett

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