Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase.

Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase. Abstract Text:

Biaoxin Chai,Ji-Yao Li,Weizhen Zhang,Erika Newman,John Ammori,Michael W Mulholland,

The melanocortin-4 receptor (MC4R) is a seven transmembrane member of the melanocortin receptor family. The GT1-1 cell line exhibits endogenous expression of MC4R. In this study, GT1-1 cells were used to study MC4R signaling pathways and to examine the effects of melanocortin receptor agonist NDP-MSH on apoptosis. MC4R mRNA expression was demonstrated by RT-PCR. Functional melanocortin receptor expression was implied by specific binding of NDP-MSH and cAMP production. NDP-MSH-stimulated GnRH release in a dose-dependent manner. Serum deprivation-induced apoptosis in GT1-1 cells, and the NDP-MSH inhibited this effect. The melanocortin receptor antagonist SHU9119 blocked the antiapoptotic actions of NDP-MSH, and the MAP kinase inhibitor PD98059 significantly attenuated the antiapoptotic effect. NDP-MSH-stimulated ERK1/2 phosphorylation in a dose-dependent manner. ERK1/2 phosphorylation could be abolished by SHU9119. In GT1-1 cells, melanocortin receptor activation causes ERK1/2 phosphorylation. In these cells, MC4R activation is also associated with antiapoptotic effects.

Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase. Publishing Authors By Initials

B Chai,JY Li,W Zhang,E Newman,J Ammori,MW Mulholland,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

PUBMED ID PMID:

MEDLINE DATE:

Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Peptides

VOLUME: 27

Page Numbers: 2846-57

Journal Abbreviation: Peptides

ISSN: 0196-9781

DAY: 27

MONTH: 06

YEAR: 2006

Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8008690

Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase. Information

Substance Name: Receptor, Melanocortin, Type 4

Registry Number: 0

Grant and Affiliation Information for Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase.

AFFILIATION: Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK054032

ACRONYM: DK

MEDLINETA: Peptides

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase Related Publications

• A survey of the "surgical and research" articles in the European Spine Journal, 2007.
• Ab initio QM/MM modelling of acetyl-CoA deprotonation in the enzyme citrate synthase.
• An efficient method for the calculation of quantum mechanics/molecular mechanics free energies.
• Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity.
• Bufadienolides from Drimia macrocentra and Urginea riparia (Hyacinthaceae: Urgineoideae).
• Chemical accuracy in QM/MM calculations on enzyme-catalysed reactions.
• Closed vertebral biopsy.
• Combined chemotherapy and surgery for hydatid bone disease.
• Comparison of different quantum mechanical/molecular mechanics boundary treatments in the reaction of the hepatitis C virus NS3 protease with the NS5A/5B substrate.
• Computational enzymology: modelling the mechanisms of biological catalysts.
• Cooperative symmetric to asymmetric conformational transition of the apo-form of scavenger decapping enzyme revealed by simulations.
• Glutamate-induced calcium transients in rat neurons of the dorsal motor nucleus of the vagus.
• Haemophilus influenzae type b infection in children in Pacific countries.
• Hopelessness in schizophrenia: the impact of symptoms and beliefs about illness.
• Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling.
• Interleukin-1beta and interleukin-6 stimulate matrix metalloproteinase-9 secretion in cultured myenteric glia.
• Intravenous infusions of a combined fat emulsion into human subjects.
• Magnetic resonance imaging of adolescent disc herniation.
• Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase.
• Non-traumatic progressive paralysis of the posterior interosseous nerve.
• Observations of biliary-pancreatic dynamics in a normal human.
• Operative treatment of carcinoma of the distal colon and rectum.
• Oxygen consumption studies with intravenous infusions of the combined fat emulsion.
• Peanut lectin binding sites in transitional cell carcinoma of the urinary bladder.
• Recurrent acute pancreatitis; observations on etiology and surgical treatment.
• Scientific basis for the treatment of low back pain.
• Substrate polarization in enzyme catalysis: QM/MM analysis of the effect of oxaloacetate polarization on acetyl-CoA enolization in citrate synthase.
• The intravenous administration of a combined fat emulsion into surgical patients.
• The surgical treatment of pancreatitis.
• Vesical apoplexy.