Melampolides from the Leaves of Smallanthus sonchifolius and Their Inhibitory Activity of LPS-Induced Nitric Oxide Production.

Melampolides from the Leaves of Smallanthus sonchifolius and Their Inhibitory Activity of LPS-Induced Nitric Oxide Production. Research Abstract Details 

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Melampolides from the Leaves of Smallanthus sonchifolius and Their Inhibitory Activity of LPS-Induced Nitric Oxide Production. Abstract Text:

Seong Su Hong,Seon A Lee,Xiang Hua Han,Min Hee Lee,Ji Sang Hwang,Jeong Sook Park,Ki-Wan Oh,Kun Han,Myung Koo Lee,Heesoon Lee,Wook Kim,Dongho Lee,Bang Yeon Hwang,Seong Su Hong,Seon A Lee,Xiang Hua Han,Min Hee Lee,Ji Sang Hwang,Jeong Sook Park,Ki-Wan Oh,Kun Han,Myung Koo Lee,Heesoon Lee,Wook Kim,Dongho Lee,Bang Yeon Hwang,

Two new melampolide-type sesquiterpene lactones, 8beta-epoxyangeloyloxy-9alpha-ethoxy-14-oxo-acanthospermolide (1) and 8beta-angeloyloxy-9alpha-ethoxy-14-oxo-acanthospermolide (2), were isolated from the leaves of yacon [Smallanthus sonchifolia (POEPP. et ENDL.) H. Robinson] along with eleven known melampolides, allo-schkuhriolide (3), enhydrin (4), polymatin A (5), fluctuanin (6), 8beta-angeloyloxy-9alpha-acetoxy-14-oxo-acanthospermolide (7), 8beta-angeloyloxy-14-oxo-acanthospermolide (8), 8beta-methacryloyloxymelampolid-14-oic acid methyl ester (9), uvedalin (10), polymatin B (11), 8beta-tigloyloxymelampolid-14-oic acid methyl ester (12), and sonchifolin (13). Their structures were established on the basis of spectroscopic evidence including 1D- and 2D-NMR experiments. All isolates were evaluated for inhibition of LPS-induced nitric oxide production in murine macrophage RAW 264.7 cells.

Melampolides from the Leaves of Smallanthus sonchifolius and Their Inhibitory Activity of LPS-Induced Nitric Oxide Production. Publishing Authors By Initials

SS Hong,SA Lee,XH Han,MH Lee,JS Hwang,JS Park,KW Oh,K Han,MK Lee,H Lee,W Kim,D Lee,BY Hwang,SS Hong,SA Lee,XH Han,MH Lee,JS Hwang,JS Park,KW Oh,K Han,MK Lee,H Lee,W Kim,D Lee,BY Hwang,

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Melampolides from the Leaves of Smallanthus sonchifolius and Their Inhibitory Activity of LPS-Induced Nitric Oxide Production. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Chemical & pharmaceutical bulletin

VOLUME: 56

Page Numbers: 199-202

Journal Abbreviation: Chem. Pharm. Bull.

ISSN: 0009-2363

DAY: 1

MONTH: Feb

YEAR: 2008

Melampolides from the Leaves of Smallanthus sonchifolius and Their Inhibitory Activity of LPS-Induced Nitric Oxide Production. Information

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LANGUAGE: eng

NlmUniqueID: 377775

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AFFILIATION: College of Pharmacy, Chungbuk National University.

Country: Japan

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MEDLINETA: Chem Pharm Bull (Tokyo)

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