Meiotic sex chromosome inactivation in the marsupial Monodelphis domestica.

Meiotic sex chromosome inactivation in the marsupial Monodelphis domestica. Research Abstract Details 

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Meiotic sex chromosome inactivation in the marsupial Monodelphis domestica. Abstract Text:

Jacey L Hornecker,Paul B Samollow,Edward S Robinson,John L Vandeberg,John R McCarrey,Jacey L Hornecker,Paul B Samollow,Edward S Robinson,John L Vandeberg,John R McCarrey,

In eutherian mammals, the X and Y chromosomes undergo meiotic sex chromosome inactivation (MSCI) during spermatogenesis in males. However, following fertilization, both the paternally (Xp) and maternally (Xm) inherited X chromosomes are active in the inner cell mass of the female blastocyst, and then random inactivation of one X chromosome occurs in each cell, leading to a mosaic pattern of X-chromosome activity in adult female tissues. In contrast, marsupial females show a nonrandom pattern of X chromosome activity, with repression of the Xp in all somatic tissues. Here, we show that MSCI also occurs during spermatogenesis in marsupials in a manner similar to, but more stable than that in eutherians. These findings support the suggestion that MSCI may have provided the basis for an early dosage compensation mechanism in mammals based solely on gametogenic events, and that random X-chromosome inactivation during embryogenesis may have evolved subsequently in eutherian mammals. genesis 45:696-708, 2007. (c) 2007 Wiley-Liss, Inc.

Meiotic sex chromosome inactivation in the marsupial Monodelphis domestica. Publishing Authors By Initials

JL Hornecker,PB Samollow,ES Robinson,JL Vandeberg,JR McCarrey,JL Hornecker,PB Samollow,ES Robinson,JL Vandeberg,JR McCarrey,

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Meiotic sex chromosome inactivation in the marsupial Monodelphis domestica. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genesis (New York, N.Y. : 2000)

VOLUME: 45

Page Numbers: 696-708

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ISSN: 1526-954X

DAY: 12

MONTH: Nov

YEAR: 2007

Meiotic sex chromosome inactivation in the marsupial Monodelphis domestica. Information

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LANGUAGE: eng

NlmUniqueID: 100931242

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AFFILIATION: Department of Biology, University of Texas at San Antonio, San Antonio, Texas.

Country: United States

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MEDLINETA: Genesis

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