Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation.

Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation. Research Abstract Details 

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Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation. Abstract Text:

Masahiro Terasawa,Hideyuki Ogawa,Yasumasa Tsukamoto,Miki Shinohara,Katsuhiko Shirahige,Nancy Kleckner,Tomoko Ogawa,

Meiotic recombination-related DNA synthesis (MRDS) was analyzed in Saccharomyces cerevisiae by specifically timed incorporation of thymidine analogs into chromosomes. Lengths and positions of incorporation tracts were determined relative to a known recombination hot spot along DNA, as was the timing and localization of incorporation relative to forming and formed synaptonemal complex in spread chromosomes. Distinct patterns could be specifically associated with the majority cross-over and non-cross-over recombination processes. The results obtained provide direct evidence for key aspects of current consensus recombination models, provide information regarding temporal and spatial relationships between non-cross-over formation and the synaptonemal complex, and raise the possibility that removal of RecA homolog Rad51 plays a key role in regulating onset of MRDS. Finally, classical observations on MRDS in Drosophila, mouse, and lily are readily mapped onto the findings presented here, providing further evidence for a broadly conserved meiotic recombination process.

Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation. Publishing Authors By Initials

M Terasawa,H Ogawa,Y Tsukamoto,M Shinohara,K Shirahige,N Kleckner,T Ogawa,

For similar chromosome structures: synaptonemal complex research abstracts see: chromosome structures: synaptonemal complex research

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Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 5965-70

Journal Abbreviation:

ISSN: 0027-8424

DAY: 23

MONTH: 03

YEAR: 2007

Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation. Keywords Mesh Terms:

KEYWORDS: Synaptonemal Complex

MESH TERMS: genetics

Chemical & Substance for Abstract: Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation. Information

Substance Name: Rec A Recombinases

Registry Number: EC 2.7.7.-

Grant and Affiliation Information for Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation.

AFFILIATION: Iwate College of Nursing, Ohgama, Takizawa, Iwate 020-0151, Japan.

Country: United States

AGENCY: United States NIGMS

GRANT: R01-GM44794

ACRONYM: GM

MEDLINETA: Proc Natl Acad Sci U S A

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