Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib.

Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib. Research Abstract Details 

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Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib. Abstract Text:

Medullary thyroid carcinoma (MTC) is an uncommon malignancy of hereditary and sporadic presentation. Mutations in the RET proto-oncogene are involved in the pathogenesis of familial MTC and >50% of the sporadic cases. Currently, there is no effective treatment for recurrent or metastatic MTC. We report here a rapid response to a sorafenib (RET and RAF kinase and vascular endothelial growth factor receptor inhibitor)-based regimen in a patient with sporadic MTC who had advanced, progressive disease and a novel RET kinase aberration at exon 11 shown in tumor tissue. [Mol Cancer Ther 2008;7(5):1001-6].

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Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular cancer therapeutics

VOLUME: 7

Page Numbers: 1001-6

Journal Abbreviation: Mol. Cancer Ther.

ISSN: 1535-7163

DAY: 29

MONTH: 04

YEAR: 2008

Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib. Information

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LANGUAGE: eng

NlmUniqueID: 101132535

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AFFILIATION: Department of Investigational Therapeutics (Phase I Program), Unit 455, Division of Cancer Medicine, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030. dshong@mdanderson.org.

Country: United States

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MEDLINETA: Mol Cancer Ther

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