Medium-term outcome of endoluminal gastroplication with the EndoCinch device in children.

Medium-term outcome of endoluminal gastroplication with the EndoCinch device in children. Research Abstract Details 

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Medium-term outcome of endoluminal gastroplication with the EndoCinch device in children. Abstract Text:

Mike Thomson,Brice Antao,Sharon Hall,Nadeem Afzal,Paul Hurlstone,C Paul Swain,Annette Fritscher-Ravens,Mike Thomson,Brice Antao,Sharon Hall,Nadeem Afzal,Paul Hurlstone,C Paul Swain,Annette Fritscher-Ravens,

OBJECTIVE: Endoluminal gastroplication (EG) is emerging as a minimally invasive procedure for the treatment of gastroesophageal reflux disease (GERD). The aim of this study is to evaluate the medium-term outcomes after EG in a pediatric patient population. PATIENTS AND METHODS: Seventeen children with a median age of 12.4 years (range 6.1-15.9 years) with GERD underwent EG using a flexible endoscopic sewing device (EndoCinch) over a period of 3 years. Three plications were placed in the gastric tissue below the lower esophageal sphincter. Drug dose requirement, pH measurements, symptom severity and frequency, and validated Quality of Life in Reflux and Dyspepsia (QOLRAD) scores were compared before EG and 1 and 3 years after EG. Statistical analysis was performed using a Wilcoxon rank-sum test and P < 0.05 was the threshold for significance. RESULTS: All patients showed an immediate posttreatment improvement in symptom severity, symptom frequency, and quality of life scores. Completed 1- and 3-year data were obtained from 16 patients. Four cases (25%) required a repeat procedure as a result of recurrence of symptoms after 2 to 24 months. Fourteen patients (88%) at 1 year and 9 patients (56%) at 3 years remained without a need for any antireflux medication. A sustained improvement in heartburn (P = 0.004), regurgitation (P = 0.017), and vomiting (P = 0.018) was seen at 3 years. The total QOLRAD score (maximum of 175) improved from a median of 87 (range 69-142) to 156 (range 111-175) at 1 year (P < 0.0001) and 153.5 (range 55-174) at 3 years (P = 0.002). CONCLUSIONS: EG is an effective and safe procedure in children. It is a viable option for the treatment of GERD refractory to or dependent on antireflux medications.

Medium-term outcome of endoluminal gastroplication with the EndoCinch device in children. Publishing Authors By Initials

M Thomson,B Antao,S Hall,N Afzal,P Hurlstone,CP Swain,A Fritscher-Ravens,M Thomson,B Antao,S Hall,N Afzal,P Hurlstone,CP Swain,A Fritscher-Ravens,

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Medium-term outcome of endoluminal gastroplication with the EndoCinch device in children. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pediatric gastroenterology and nutritio

VOLUME: 46

Page Numbers: 172-7

Journal Abbreviation: J. Pediatr. Gastroenterol. Nut

ISSN: 1536-4801

DAY: 28

MONTH: Feb

YEAR: 2008

Medium-term outcome of endoluminal gastroplication with the EndoCinch device in children. Information

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LANGUAGE: eng

NlmUniqueID: 8211545

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AFFILIATION: Centre for Paediatric Gastroenterology, Sheffield Children's Hospital, UK. mike.thomson@sch.nhs.uk

Country: United States

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MEDLINETA: J Pediatr Gastroenterol Nutr

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