Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient mice.

Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient mice. Abstract Text:

Rick W Wright,Tracy Allen,Hossam B El-Zawawy,Michael D Brodt,Matthew J Silva,Corey S Gill,Linda J Sandell,

Medial collateral ligament (MCL) injuries heal by a wound repair scar response controlled by a complex cellular and cytokine environment. Many enzymes participate in wound repair, particularly the matrix metalloproteinases. We hypothesize macrophage metalloelastase (MME/MMP-12) deficiency results in impaired healing of MCL injury. One hundred fifty MME-deficient and 150 WT (MME+/+) mice underwent knee MCL transection with the opposite knee as a sham operated control. Mice were sacrificed at 3, 7, 28, 42, and 56 days. At each of the five time points, 15 mice were utilized for biological and 15 were utilized for biomechanical testing. Outcome measures were the presence of macrophages to represent the inflammatory phase of wound healing, collagen synthesis to assay for matrix repair, and biomechanical testing for repair strength. Immunohistochemistry demonstrated significantly fewer macrophages in cut MCLs from MME-deficient mice versus wild-type (WT) mice at 3, 7, 28, and 42 days (all p

Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient mice. Publishing Authors By Initials

RW Wright,T Allen,HB El-Zawawy,MD Brodt,MJ Silva,CS Gill,LJ Sandell,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

PUBMED ID PMID:

MEDLINE DATE:

Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of orthopaedic research : official publica

VOLUME: 24

Page Numbers: 2106-13

Journal Abbreviation: J. Orthop. Res.

ISSN: 0736-0266

DAY: 3

MONTH: Nov

YEAR: 2006

Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8404726

Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient mice. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: surgery

Chemical & Substance for Abstract: Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient mice. Information

Substance Name: Matrix Metalloproteinase 12

Registry Number: EC 3.4.24.65

Grant and Affiliation Information for Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient mice.

AFFILIATION: Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, Missouri, USA. RWWright1@aol.com

Country: United States

AGENCY: United States PHS

GRANT: R01 36994

ACRONYM:

MEDLINETA: J Orthop Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Medial collateral ligament healing in macrophage metalloelastase MMP-12-deficient mice Related Publications

• A novel tumor necrosis factor alpha-responsive CCAAT/enhancer binding protein site regulates expression of the cartilage-derived retinoic acid-sensitive protein gene in cartilage.
• Computational identification and functional validation of regulatory motifs in cartilage-expressed genes.
• Focus on molecules: Homeobox protein Chx10.
• Interactions between visually and electrically elicited saccades before and after superior colliculus and frontal eye field ablations in the rhesus monkey.
• Long-term cellular and regional specificity of the photoreceptor toxin, iodoacetic acid (IAA), in the rabbit retina.
• Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient mice.
• Nuclear protein TIA-1 regulates COL2A1 alternative splicing and interacts with precursor mRNA and genomic DNA.
• Site-1 protease is essential for endochondral bone formation in mice.
• Smoking delays chondrogenesis in a mouse model of closed tibial fracture healing.
• Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes.
• Type IIA procollagen containing the cysteine-rich amino propeptide is deposited in the extracellular matrix of prechondrogenic tissue and binds to TGF-beta1 and BMP-2.
• Yolk testosterone modulates persistence of neophobic responses in adult zebra finches, Taeniopygia guttata.
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Visual control in the preparation of ampules.]