Mechanoregulation of monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells.

Mechanoregulation of monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells. Research Abstract Details 

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Mechanoregulation of monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells. Abstract Text:

Thomas M Guest,George Vlastos,Fadi M F Alameddine,W Robert Taylor,

The authors have previously shown that arterial wall strain mediates the development of vessel wall inflammation in experimental hypertension. The current studies explore the mechanoregulation of monocyte chemoattractant protein-1 (MCP-1), a potent pro-inflammatory chemokine, by mitogen-activated protein kinases (MAPK) and oxidative stress. Rat aortic smooth muscle (RASM) cells were subjected to cyclic strain on a uniform biaxial strain device. Strain rapidly activated both ERK1/2(MAPK) and p38(MAPK), with peak activation at 5 min. Strain induced a twofold increase in MCP-1 mRNA, which was attenuated by PD 98059, a specific ERK1/2(MAPK) inhibitor, and SB 203580, a specific p38(MAPK) inhibitor. Cyclic strain also increased production of superoxide anion via an NADPH oxidase-dependent mechanism. To assess the potential role of reactive oxygen species in MAPK activation, cells were stretched in the presence of N-acetylcysteine, which had no effect on p38(MAPK) activation, but significantly inhibited ERK1/2(MAPK) activation and MCP-1 expression. In conclusion, redox-sensitive activation of ERK1/2(MAPK) and redox-insensitive activation of p38(MAPK) regulate straininduced MCP-1 expression in RASM cells. These findings define a role for MAPK signal transduction in establishing a pro-inflammatory state in the arterial wall, and thus implicate a potential molecular link between arterial wall strain and atherosclerosis.

Mechanoregulation of monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells. Publishing Authors By Initials

TM Guest,G Vlastos,FM Alameddine,WR Taylor,

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Mechanoregulation of monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Antioxidants & redox signaling

VOLUME: 8

Page Numbers: 1461-71

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ISSN: 1523-0864

DAY: 3

MONTH: 12

YEAR: 2007

Mechanoregulation of monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Mechanoregulation of monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells.

AFFILIATION: Division of Cardiology, Atlanta VAMC and Emory University School of Medicine, Atlanta, Georgia 30322, USA.

Country: United States

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MEDLINETA: Antioxid Redox Signal

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