Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling.

Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling. Research Abstract Details 

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Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling. Abstract Text:

Darwin Jeyaraj,Lance D Wilson,Jia Zhong,Chris Flask,Jeffrey E Saffitz,Isabelle ,Xin Yu,David S Rosenbaum,

BACKGROUND: Altered electrical activation of the heart by pacing or disease induces profound ventricular electrical remodeling (VER), manifested electrocardiographically as T-wave memory and ultimately as deleterious mechanical remodeling from heterogeneous strain. Although T-wave memory is associated with altered expression of sarcolemmal ion channels, the biophysical mechanisms responsible for triggering remodeling of cardiac ion channels are unknown. METHODS AND RESULTS: To test the hypothesis that mechanoelectrical feedback triggered by regional strain is a mechanism for VER, dogs (n=6) underwent 4 weeks of ventricular pacing to induce VER. Multisegment transmural optical action potential imaging of left ventricular wedges revealed profound and selective prolongation of action potential duration in late-activated (288+/-29 ms) compared with early-activated (250+/-9 ms) myocardial segments (P<0.05), providing the first experimental evidence that amplification of repolarization gradients between segments of left ventricle is the electrophysiological basis for T-wave memory. In vivo tagged magnetic resonance imaging revealed a 2-fold and preferential increase in circumferential strain in late-activated segments of myocardium, which exactly coincided with segments undergoing VER. VER could not be attributed to structural remodeling because it occurred without any histological evidence of cellular hypertrophy. CONCLUSIONS: The mechanism responsible for triggering remodeling of ion channel function in VER was locally enhanced circumferential strain. These data suggest a novel mechanoelectrical feedback mechanism for inducing physiological and potentially deleterious electrical heterogeneities in the heart.

Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling. Publishing Authors By Initials

D Jeyaraj,LD Wilson,J Zhong,C Flask,JE Saffitz,I ,X Yu,DS Rosenbaum,

For similar biomechanics: stress, mechanical research abstracts see: biomechanics: stress, mechanical research

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Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Circulation

VOLUME: 115

Page Numbers: 3145-55

Journal Abbreviation: Circulation

ISSN: 1524-4539

DAY: 11

MONTH: 06

YEAR: 2007

Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling. Information

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LANGUAGE: eng

NlmUniqueID: 147763

Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling. Keywords Mesh Terms:

KEYWORDS: Stress, Mechanical

MESH TERMS: physiology

Chemical & Substance for Abstract: Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling. Information

Substance Name: Ion Channels

Registry Number: 0

Grant and Affiliation Information for Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling.

AFFILIATION: Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, 2500 MetroHealth Dr, Cleveland, OH 44109-1998, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01-HL54807

ACRONYM: HL

MEDLINETA: Circulation

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