Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis.

Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis. Research Abstract Details 

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Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis. Abstract Text:

Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic neurotransmitter release can be induced within minutes following postsynaptic glutamate receptor blockade. The rapid induction of synaptic homeostasis is independent of new protein synthesis and does not require evoked neurotransmission, indicating that a change in the efficacy of spontaneous quantal release events is sufficient to trigger the induction of synaptic homeostasis. Finally, both the rapid induction and the sustained expression of synaptic homeostasis are blocked by mutations that disrupt the pore-forming subunit of the presynaptic Ca(V)2.1 calcium channel encoded by cacophony. These data confirm the presynaptic expression of synaptic homeostasis and implicate presynaptic Ca(V)2.1 in a homeostatic retrograde signaling system.

Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis. Publishing Authors By Initials

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neuron

VOLUME: 52

Page Numbers: 663-77

Journal Abbreviation: Neuron

ISSN: 0896-6273

DAY: 22

MONTH: Nov

YEAR: 2006

Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8809320

Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis. Information

Substance Name: voltage-dependent calcium channel (P-Q t

Registry Number: 0

Grant and Affiliation Information for Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis.

AFFILIATION: Department of Biochemistry and Biophysics, Neuroscience Program, University of California, San Francisco, 1550 4th Street, Rock Hall 4th Floor North, San Francisco, California 94158, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS39313

ACRONYM: NS

MEDLINETA: Neuron

REFSOURCE: Neuron. 2006 Nov 22;52(4):569-71

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