Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics.

Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics. Research Abstract Details 

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Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics. Abstract Text:

Thomas W McAllister,Laura A Flashman,Brenna C McDonald,Andrew J Saykin,

Cognitive complaints are a frequent source of distress and disability after mild and moderate traumatic brain injury (TBI). While there are deficits in several cognitive domains, many aspects of these complaints and deficits suggest that problems in working memory (WM) play an important role. Functional imaging studies in healthy individuals have outlined the neural substrate of WM and have shown that regions important in WM circuitry overlap with regions commonly vulnerable to damage in TBI. Use of functional MRI (fMRI) in individuals with mild and moderate TBI suggests that they can have problems in the activation and allocation of WM, and several lines of evidence suggest that subtle alterations in central catecholaminergic sensitivity may underlie these problems. We review the evidence from fMRI and neurogenetic studies that support the role of catecholaminergic dysregulation in the etiology of WM complaints and deficits after mild and moderate TBI.

Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics. Publishing Authors By Initials

TW McAllister,LA Flashman,BC McDonald,AJ Saykin,

For similar investigative techniques: epidemiologic methods: data collection: records as topic: medical records: trauma severity indices research abstracts see: investigative techniques: epidemiologic methods: data collection: records as topic: medical records: trauma severity indices research

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Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of neurotrauma

VOLUME: 23

Page Numbers: 1450-67

Journal Abbreviation: J. Neurotrauma

ISSN: 0897-7151

DAY: 3

MONTH: Oct

YEAR: 2006

Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics. Information

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LANGUAGE: eng

NlmUniqueID: 8811626

Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics. Keywords Mesh Terms:

KEYWORDS: Trauma Severity Indices

MESH TERMS: physiology

Chemical & Substance for Abstract: Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics. Information

Substance Name: Catechol O-Methyltransferase

Registry Number: EC 2.1.1.6

Grant and Affiliation Information for Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics.

AFFILIATION: Section of Neuropsychiatry, Neuropsychology Program, Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA. thomas.w.mcallister@dartmouth.edu

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS40472

ACRONYM: NS

MEDLINETA: J Neurotrauma

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