Mechanisms of seizure propagation in a cortical model.

Mechanisms of seizure propagation in a cortical model. Research Abstract Details 

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Mechanisms of seizure propagation in a cortical model. Abstract Text:

Mark A Kramer,Andrew J Szeri,James W Sleigh,Heidi E Kirsch,

We consider a mathematical model of mesoscopic human cortical ictal electrical activity. We compare the model results with ictal electrocortical data recorded from three human subjects and show how the two agree. We determine that, in the model system, seizures result from increased connectivity between excitatory and inhibitory cell populations, or from decreased connectivity within either excitatory or inhibitory cell populations. We compare the model results with the disinhibition and 4-AP models of epilepsy and suggest how the model may guide the development of new anticonvulsant therapies.

Mechanisms of seizure propagation in a cortical model. Publishing Authors By Initials

MA Kramer,AJ Szeri,JW Sleigh,HE Kirsch,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: temporal lobe research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: temporal lobe research

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Mechanisms of seizure propagation in a cortical model. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of computational neuroscience

VOLUME: 22

Page Numbers: 63-80

Journal Abbreviation:

ISSN: 0929-5313

DAY: 19

MONTH: 09

YEAR: 2006

Mechanisms of seizure propagation in a cortical model. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9439510

Mechanisms of seizure propagation in a cortical model. Keywords Mesh Terms:

KEYWORDS: Temporal Lobe

MESH TERMS: physiology

Chemical & Substance for Abstract: Mechanisms of seizure propagation in a cortical model. Information

Substance Name: 4-Aminopyridine

Registry Number: 504-24-5

Grant and Affiliation Information for Mechanisms of seizure propagation in a cortical model.

AFFILIATION: Applied Science and Technology Graduate Group, University of California, Berkeley, CA 94720-1740, USA.

Country: United States

AGENCY: United States NINDS

GRANT: K23 NS 047100

ACRONYM: NS

MEDLINETA: J Comput Neurosci

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